(2E)-2-(3,4-dihydro-1H-anthracen-2-ylidene)acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: (2E)-2-(3,4-dihydro-1H-anthracen-2-ylidene)acetic acid
• 化学式: C₁₆H₁₄O₂
• 分子量: 238.28
• InChiKey: BZRFVNPWMWKUPX-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compounds and methods of use thereof for treating tumors
  申请人：Georgetown University

  公开号：US10160716B2

  公开（公告）日：2018-12-25

  The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.

  本发明包括新型化合物及其药学上可接受的盐，以及包括治疗或预防有效量的此类化合物或其药学上可接受的盐的组合物。本发明还包括治疗或预防与细胞异常生长有关的疾病和失调的方法，例如，治疗或预防癌症或肿瘤生长的方法，这些方法包括向有需要的哺乳动物施用包含治疗或预防有效量的本发明化合物或其药学上可接受的盐的组合物。
• Compounds and Methods of Use Thereof for Treating Tumors
  申请人：Georgetown University

  公开号：US20150344440A1

  公开（公告）日：2015-12-03

  The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.
• US9695108B2
  申请人：——

  公开号：US9695108B2

  公开（公告）日：2017-07-04
• [EN] COMPOUNDS AND METHODS OF USE THEREOF FOR TREATING TUMORS<br/>[FR] COMPOSÉS ET LEURS PROCÉDÉS D'UTILISATION POUR TRAITER DES TUMEURS
  申请人：UNIV GEORGETOWN

  公开号：WO2014032019A2

  公开（公告）日：2014-02-27

  The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.