1-[4-(3,6-Dibromo-1,2-dimethoxycarbazol-9-yl)anilino]propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-(3,6-Dibromo-1,2-dimethoxycarbazol-9-yl)anilino]propan-2-ol
• 英文别名: 1-[4-(3,6-dibromo-1,2-dimethoxycarbazol-9-yl)anilino]propan-2-ol
• 化学式: C₂₃H₂₂Br₂N₂O₃
• 分子量: 534.2
• InChiKey: OVKMZMUNHXDFAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  55.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] NEUROPROTECTIVE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS NEUROPROTECTEURS ET LEUR UTILISATION
  申请人：UNIV TEXAS

  公开号：WO2015070234A9

  公开（公告）日：2015-12-10
• PRO-NEUROGENIC COMPOUNDS
  申请人：Board of Regents of the University of Texas System

  公开号：EP2925129A1

  公开（公告）日：2015-10-07
• NEUROPROTECTIVE COMPOUNDS AND USE THEREOF
  申请人：Board of Regents of the University of Texas System

  公开号：EP3068388A2

  公开（公告）日：2016-09-21
• [EN] PRO-NEUROGENIC COMPOUNDS<br/>[FR] COMPOSÉS PRO-NEUROGÈNES
  申请人：UNIV TEXAS

  公开号：WO2014031125A1

  公开（公告）日：2014-02-27

  This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.
• [EN] NEUROPROTECTIVE CHEMICALS AND METHODS FOR IDENTIFYING AND USING SAME<br/>[FR] PRODUITS CHIMIQUES NEUROPROTECTEURS ET LEURS PROCÉDÉS D'IDENTIFICATION ET D'UTILISATION
  申请人：UNIV TEXAS

  公开号：WO2015070237A9

  公开（公告）日：2015-07-23

  [EN] Provided herein is a method for identifying a compound having neuroprotective activity, including: providing a population of cells treated with a test compound for a first period of time; subjecting the population of cells to doxorubicin for a second period of time; and determining survival rate of the population of cells; wherein an increase in the survival rate compared to a control that is not treated with the test compound is indicative of neuroprotective activity of the test compound. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with neuronal cell death.
  [FR] L'invention concerne un procédé d'identification d'un composé ayant une action neuroprotectrice, ce procédé consistant à : obtenir une population de cellules traitées avec un composé test sur une première durée; soumettre la population de cellules à la doxorubicine pendant une seconde durée et déterminer le taux de survie de la population de cellules; une augmentation du taux de survie comparée à un témoin qui n'est pas traité avec le composé test indique l'action neuroprotectrice de ce composé test. L'invention concerne également des composés identifiés à partir de ce procédé. Ces composés peuvent être utilisés pour traiter diverses maladies, divers troubles ou états associés à la mort cellulaire neuronale.