N-(2,5-Dimethylphenyl)-2,4,6-tris(propan-2-YL)benzene-1-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,5-Dimethylphenyl)-2,4,6-tris(propan-2-YL)benzene-1-sulfonamide
• 英文别名: N-(2,5-dimethylphenyl)-2,4,6-tri(propan-2-yl)benzenesulfonamide
• 化学式: C₂₃H₃₃NO₂S
• mdl: MFCD00807750
• 分子量: 387.6
• InChiKey: COJYIFKJMHOZJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF
  申请人：NOVOMEDIX, LLC

  公开号：US20140155477A1

  公开（公告）日：2014-06-05

  Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

  本文提供了替代的双芳基磺酰胺化合物、包含该化合物的药物组合物、其制备方法以及使用方法。这些化合物可用于治疗、预防和/或改善各种疾病，包括癌症和增殖性疾病。在一种实施例中，本文提供的化合物调节蛋白质翻译的启动。在一种实施例中，本文提供的化合物与手术、放射治疗、免疫治疗和/或一个或多个其他抗癌药物结合使用，用于治疗、预防和/或改善癌症和增殖性疾病。
• Substituted biaryl sulfonamides and the use thereof
  申请人：NovoMedix, LLC

  公开号：US10040757B2

  公开（公告）日：2018-08-07

  Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

  本文提供了取代的双芳基磺酰胺化合物、包含这些化合物的药物组合物、其制备方法和使用方法。本文提供的化合物可用于治疗、预防和/或改善各种疾病，包括癌症和增殖性疾病。在一个实施方案中，本文提供的化合物可调节蛋白质翻译的启动。在一个实施方案中，本文提供的化合物与手术、放射治疗、免疫治疗和/或一种或多种额外的抗癌药物联合使用，用于治疗、预防和/或改善癌症和增殖性疾病。
• US9156781B2
  申请人：——

  公开号：US9156781B2

  公开（公告）日：2015-10-13
• US9604924B2
  申请人：——

  公开号：US9604924B2

  公开（公告）日：2017-03-28
• [EN] SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF<br/>[FR] SULFONAMIDES BIARYLIQUES SUBSTITUÉS ET LEUR UTILISATION
  申请人：NOVOMEDIX LLC

  公开号：WO2014085633A1

  公开（公告）日：2014-06-05

  Provided herein are substituted biaryl sulfonamide compounds of formula (I), pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.