N-(3-methyl-5-pyridin-4-ylphenyl)-1,3-thiazol-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(3-methyl-5-pyridin-4-ylphenyl)-1,3-thiazol-2-amine
• 化学式: C₁₅H₁₃N₃S
• 分子量: 267.4
• InChiKey: MNGTWHALHRXBAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method And Compositions For Improving Selective Catabolysis And Viability In Cells Of Keratin Surfaces
  申请人：ELC Management LLC

  公开号：US20140193391A1

  公开（公告）日：2014-07-10

  A composition for treating keratin surfaces to stimulate selective catabolysis and improve cellular viability comprising at least one autophagy activator and at least one DNA repair enzyme, and a method for improving selective catabolysis and cellular viability by treating with the composition.

  一种用于处理角蛋白表面以刺激选择性分解并改善细胞生存能力的组合物，包括至少一种自噬激活剂和至少一种DNA修复酶，以及一种通过使用该组合物来改善选择性分解和细胞生存能力的方法。
• Methods and compositions for treating skin to resolve inflammation and screening for actives that stimulate pro-resolution pathways
  申请人：ELC Management LLC

  公开号：US10010492B2

  公开（公告）日：2018-07-03

  Compositions and methods for treating inflamed skin with Pro-Resolution Pathway Stimulators that may be Inflammatory Metabolite Inhibitors, Pro-Resolving Activators, or combinations thereof, and a method for screening active ingredients for activity as Pro-Resolution Pathway Stimulators for incorporation into topical cosmetic products.

  使用可作为炎症代谢物抑制剂、促溶解激活剂或其组合的促溶解途径刺激剂治疗炎症皮肤的组合物和方法，以及筛选活性成分作为促溶解途径刺激剂用于外用化妆品的方法。
• Method and compositions for improving selective catabolysis in cells of keratin surfaces
  申请人：ELC Management LLC

  公开号：US10383815B2

  公开（公告）日：2019-08-20

  A skin care composition for stimulating selective catabolysis in cells of keratin surfaces comprising at least one autophagy activator and at least one proteasome activator, and a method for improving selective catabolysis in cells of keratin surfaces by treating with the composition.

  一种用于刺激角质表面细胞选择性分解的护肤组合物，包含至少一种自噬激活剂和至少一种蛋白酶体激活剂，以及一种通过使用该组合物进行处理来改善角质表面细胞选择性分解的方法。
• Cosmetic compositions
  申请人：ELC MANAGEMENT LLC

  公开号：US10660420B2

  公开（公告）日：2020-05-26

  A topical composition comprising a Polymer, a high molecular weight hyaluronic acid (HWM HA) and/or its salt, a low molecular weight hyaluronic acid (LWM HA) and/or its salt, and a polyamino acid and/or its salt; and water and a method for identifying a test polymer that forms a micro-mesh structure when combined with such ingredients.

  一种外用组合物，包含聚合物、高分子量透明质酸（HWM HA）和/或其盐、低分子量透明质酸（LWM HA）和/或其盐、聚氨基酸和/或其盐；以及水和一种用于鉴定与上述成分结合后形成微网状结构的测试聚合物的方法。
• COMPOSITIONS FOR IMPROVING SELECTIVE CATABOLYSIS IN CELLS OF KERATIN SURFACES
  申请人：ELC Management LLC

  公开号：EP2897582B1

  公开（公告）日：2018-12-05