methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]imidazole-4-carboxylate;hydrate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]imidazole-4-carboxylate;hydrate
• 化学式: C24H28N6O4
• 分子量: 464.5
• InChiKey: KXORRVOTMFLGGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.86
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• FAST DISSOLVING OCULAR INSERT
  申请人：University Of The Witwatersrand, Johannesburg

  公开号：EP2895153A1

  公开（公告）日：2015-07-22
• Fast Dissolving Ocular Insert
  申请人：UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG

  公开号：US20150209275A1

  公开（公告）日：2015-07-30

  This invention relates to a pharmaceutical dosage form, particularly to a topical ocular pharmaceutical dosage form comprising a polymeric matrix of polyethylene oxide block copolymer, preferably polyoxyethylene-polyoxypropylene block copolymer and hydroxpropyl cellulose, and a pharmaceutically active ingredient incorporated within the matrix. The invention extends to a method of manufacturing the pharmaceutical dosage form.
• [EN] FAST DISSOLVING OCULAR INSERT<br/>[FR] INSERT OCULAIRE À DISSOLUTION RAPIDE
  申请人：UNIV WITWATERSRAND JHB

  公开号：WO2014041485A1

  公开（公告）日：2014-03-20

  This invention relates to a pharmaceutical dosage form, particularly to a topical ocular pharmaceutical dosage form comprising a polymeric matrix of polyethylene oxide block copolymer, preferably polyoxyethylene-polyoxypropylene block copolymer and hydroxpropyl cellulose, and a pharmaceutically active ingredient incorporated within the matrix. The invention extends to a method of manufacturing the pharmaceutical dosage form.