N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-[2-(2-methoxyethoxy)ethoxy]ethyl]benzamide
• 化学式: C₁₄H₂₁NO₄
• 分子量: 267.32
• InChiKey: OOMUKOZLYTZUSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• KINASE INHIBITOR
  申请人：Topivert Pharma Limited

  公开号：US20140296271A1

  公开（公告）日：2014-10-02

  There is provided a compound of formula I, which compound has antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases, e.g., Src and Lck) and has use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了一种化合物I，该化合物具有抗炎活性（例如通过抑制p38丝裂原活化蛋白激酶酶家族的一个或多个成员、Syk激酶和酪氨酸激酶Src和Lck等家族成员之一），并且可用于治疗，包括在药物组合中，特别是用于治疗炎症性疾病，包括肺部、眼睛和肠道的炎症性疾病。
• US8927563B2
  申请人：——

  公开号：US8927563B2

  公开（公告）日：2015-01-06
• [EN] HISTONE DEACETYLASE INHIBITORS FOR ENHANCING ACTIVITY OF ANTIFUNGAL AGENTS<br/>[FR] INHIBITEURS D'HISTONE DÉSACÉTYLASE POUR L'ACCROISSEMENT DE L'ACTIVITÉ D'AGENTS ANTIFONGIQUES
  申请人：METHYLGENE INC

  公开号：WO2014041424A1

  公开（公告）日：2014-03-20

  The present invention relates to compositions and methods to selectively treat fungal infection. More particularly, the invention relates to compounds, compositions thereof, and methods for selectively enhancing fungal sensitivity to antifungal compounds. The compositions of the invention are comprised of a combination of a histone deacetylase inhibitor, or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, agricultural formulation, prodrug or complex thereof, and an antifungal agent, the histone deacetylase inhibitor being a compound of Formula (I).