Mesyloxybenzyl isobutylbenzenesulfonamide | 853758-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Mesyloxybenzyl isobutylbenzenesulfonamide
• 英文别名: [4-[[benzenesulfonyl(2-methylpropyl)amino]methyl]phenyl] methanesulfonate
• CAS: 853758-16-4
• 化学式: C₁₈H₂₃NO₅S₂
• 分子量: 397.5
• InChiKey: OJLQAKFAPWMHNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  97.5
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Modulation of dynein in skin
  申请人：Avon Products, Inc.

  公开号：EP2889384A1

  公开（公告）日：2015-07-01

  Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that modulate dynein expression in the skin. Also provided are methods for screening for substances which modulate dynein expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.

  本研究提供了预防、改善或减少皮肤老化迹象的方法，这些方法采用了可调节皮肤中染料蛋白表达的活性剂。此外，还提供了筛选可调节染料蛋白表达水平的物质的方法，以及使用筛选方案确定的活性剂治疗皮肤的方法。
• Method of treating skin with microRNA modulators
  申请人：AVON PRODUCTS, INC.

  公开号：EP2987534A1

  公开（公告）日：2016-02-24

  Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that suppress or down-regulate microRNA expression in dermal fibroblast, resulting in enhanced production of collagen, elastin and/or fibrillin in the skin. Also provided are methods for screening for activity against specific microRNAs and the methods of using active agents identified by the screening protocol in the treatment of skin.

  本发明提供了预防、改善或减少皮肤老化迹象的方法，这些方法采用的活性剂可抑制或下调真皮成纤维细胞中 microRNA 的表达，从而增强皮肤中胶原蛋白、弹性蛋白和/或纤维蛋白的生成。此外，还提供了针对特定 microRNA 的活性筛选方法，以及使用筛选方案确定的活性剂治疗皮肤的方法。
• Collagen and elastin stimulating compositions and uses thereof
  申请人：Leeson Daniel Thorn

  公开号：US10195136B2

  公开（公告）日：2019-02-05

  Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of Justicia ventricosa, Archidendron clypearia, Abrus fruticulosus, or combinations thereof and a cosmetically acceptable vehicle.

  本发明提供了用于预防、改善或减少皮肤老化迹象的方法和组合物，这些方法和组合物采用了 Justicia ventricosa、Archidendron clypearia、Abrus fruticulosus 或其组合的植物提取物以及化妆品可接受的载体。
• Compositions and methods for stimulation MAGP-1 to improve the appearance of skin
  申请人：New Avon LLC

  公开号：US10849840B2

  公开（公告）日：2020-12-01

  The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.

  本公开涉及治疗、预防和改善皮肤状况和美学外观的方法，特别是通过施用一种或多种天然化合物或提取物来治疗、预防、改善、减少和/或消除皮肤细纹和/或皱纹，这些天然化合物或提取物可刺激 MAGP-1 的表达并改善老化和/或光损伤皮肤的外观。本发明的组合物可局部施用到皮肤上，或通过定向方法输送到需要的部位，其用量可有效改善皮肤状况和外观美感。
• COMPOSITIONS AND METHODS FOR STIMULATING MAGP-1 TO IMPROVE THE APPEARANCE OF SKIN
  申请人：Avon Products, Inc.

  公开号：EP2588593A2

  公开（公告）日：2013-05-08