1-[Hydroxy(phenyl)methyl]pyrrolidine-2,5-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[Hydroxy(phenyl)methyl]pyrrolidine-2,5-dione
• 英文别名: 1-[hydroxy(phenyl)methyl]pyrrolidine-2,5-dione
• 化学式: C₁₁H₁₁NO₃
• 分子量: 205.21
• InChiKey: YWAUTGYAAQLPQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] METHOD FOR DETERMINING THE HER2 STATUS OF A MALIGNANCY<br/>[FR] PROCÉDÉ DE DÉTERMINATION DU STATUT HER2 D'UNE TUMEUR MALIGNE
  申请人：AFFIBODY AB

  公开号：WO2014013016A1

  公开（公告）日：2014-01-23

  A method for determining the HER2 status of a malignancy is provided. The method comprises administering, to a mammalian subject having a malignancy suspected of being HER2 positive, a tracer molecule comprising a HER2 binding polypeptide; measuring the amount of said tracer molecule present in said malignancy using medical imaging equipment at two time points t1 and t2 to yield a first and second value; comparing said first and second values, and if said second value is greater than said first value, concluding that the malignancy of said subject is HER2 positive.