N-[4-[2-[benzyl(ethyl)amino]ethyl]phenyl]-4-phenyl-1,3-thiazol-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[2-[benzyl(ethyl)amino]ethyl]phenyl]-4-phenyl-1,3-thiazol-2-amine
• 化学式: C₂₆H₂₇N₃S
• 分子量: 413.6
• InChiKey: IKYAXJDLCDBNPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  56.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING<br/>[FR] INHIBITEURS DOUBLES À PETITES MOLÉCULES DE TRPV4 ET TRPA1 POUR LA DÉSINFECTION ET L'ANESTHÉSIE
  申请人：UNIV DUKE

  公开号：WO2017177200A1

  公开（公告）日：2017-10-12

  Provided are methods of sanitizing a subject, and methods of anesthetizing a subject. Further provided are methods of treating and/or preventing dermatological disorders, reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.

  提供了对主体进行消毒的方法，以及对主体进行麻醉的方法。此外，还提供了治疗和/或预防皮肤疾病、减少皮肤炎症、减轻疼痛和/或减轻瘙痒的方法。这些方法可能包括向主体施用有效量的TRPA1和/或TRPV4抑制剂。此外，还提供了包含TRPA1和/或TRPV4抑制剂化合物的组合物，该组合物与适用于局部应用的载体、载具或稀释剂结合。
• [EN] TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH<br/>[FR] INHIBITEURS ET DE TRPA1 DE TRPV4 ET PROCÉDÉS POUR LES UTILISER DANS DES CAS D'INFLAMMATION ET DE PRURIT SPÉCIFIQUE D'UN ORGANE
  申请人：UNIV DUKE

  公开号：WO2016028325A1

  公开（公告）日：2016-02-25

  Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.

  提供了治疗和/或预防皮肤病的方法。提供了减少皮肤炎症、减轻疼痛和/或减少瘙痒的方法，适用于需要的对象。这些方法可能包括向对象施加有效量的TRPA1和/或TRPV4抑制剂。此外，提供了包括TRPA1和/或TRPV4抑制剂化合物的组合物，结合了适用于局部应用的载体、车载物或稀释剂。
• TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH
  申请人：Duke University

  公开号：US20160199363A1

  公开（公告）日：2016-07-14

  Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.

  提供了治疗和/或预防皮肤病的方法。提供了一种在需要的受试对象中减少皮肤炎症、减轻疼痛和/或减少瘙痒的方法。这些方法可能包括向受试对象施用足够剂量的TRPA1和/或TRPV4抑制剂。进一步提供了包括TRPA1和/或TRPV4抑制剂化合物的组合物，该组合物与适用于局部应用的载体、车辆或稀释剂相结合。
• TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
  申请人：Duke University

  公开号：US10329265B2

  公开（公告）日：2019-06-25

  Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.

  提供了治疗和/或预防皮肤病的方法。提供了减轻皮肤炎症、减轻疼痛和/或减轻需要者瘙痒的方法。这些方法可包括向受试者施用有效量的 TRPA1 和/或 TRPV4 抑制剂。进一步提供的是包括 TRPA1 和/或 TRPV4 抑制剂化合物的组合物，该化合物与适合局部应用的载体、载体或稀释剂结合使用。
• ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION AND ITCH
  申请人：Duke University

  公开号：US20150252035A1

  公开（公告）日：2015-09-10

  Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPV4 inhibitor. Further provided are compositions including a TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application. Further provided is a transgenic mouse whose genome includes deletions of the Trpv4 gene in keratinocytes of the epidermis, wherein said transgenic mouse is a knockout for the Trpv4 gene in keratinocytes of the epidermis following keratinocyte-specific activation and expression of a site-specific recombination enzyme.