N-[4-[2-[benzyl(methyl)amino]ethyl]phenyl]-N'-(1-phenylethenyl)ethanimidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-[2-[benzyl(methyl)amino]ethyl]phenyl]-N'-(1-phenylethenyl)ethanimidamide
• 化学式: C₂₆H₂₉N₃
• 分子量: 383.5
• InChiKey: JGKOOGDASWFWMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  27.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION AND ITCH<br/>[FR] ACTIVATION DU CANAL IONIQUE TRPV4 PAR STIMULI PHYSIQUES ET RÔLE CRITIQUE DE TRPV4 DANS L'INFLAMMATION ET LA DÉMANGEAISON SPÉCIFIQUE À UN ORGANE
  申请人：UNIV DUKE

  公开号：WO2014008477A2

  公开（公告）日：2014-01-09

  Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPV4 inhibitor. Further provided are compositions including a TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application. Further provided is a transgenic mouse whose genome includes deletions of the Trpv4 gene in keratinocytes of the epidermis, wherein said transgenic mouse is a knockout for the Trpv4 gene in keratinocytes of the epidermis following keratinocyte-specific activation and expression of a site-specific recombination enzyme.