4-pentylfuranone | 78816-30-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 4-pentylfuranone
• 英文别名: 4-pentyl-5H-furan-2-one；4-pentyl-2(5H)-furanone；3-pentyl-2H-furan-5-one
• CAS: 78816-30-5
• 化学式: C₉H₁₄O₂
• 分子量: 154.209
• InChiKey: MYQNQHDMGJLASV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-pentylcyclopropene-3-carboxylic acid 在 三氯乙酸 作用下， 以 四氯化碳 、 二氯甲烷 为溶剂， 反应 0.08h， 以80%的产率得到4-pentylfuranone
  参考文献：
  名称：

  Regioselective catalytic addition of proton-donor reagents to esters of 1-alkylcyclopropene-3-carboxylic acids

  摘要：

  DOI：

  10.1007/bf01455477

文献信息

• [EN] COMBINATIONS OF COX AND VASOPRESSIN INHIBITORS FOR THE TREATMENT OF DISMENORRHEA<br/>[FR] ASSOCIATIONS COMPOSEES DES INHIBITEURS DE COX ET DE LA VASOPRESSINE, DESTINEES AU TRAITEMENT DE LA DYSMENORRHEE
  申请人：PFIZER LTD

  公开号：WO2005039565A1

  公开（公告）日：2005-05-06

  The use of a combination of (A) a vasopressin receptor family antagonist or a pharmaceutically acceptable derivative thereof, and (B) a COX inhibitor or a pharmaceutically acceptable derivative thereof, is described for the treatment or prophylaxis of dysmenorrhoea.

  使用（A）一种抗利尿激素受体家族拮抗剂或其药用可接受的衍生物，以及（B）一种COX抑制剂或其药用可接受的衍生物的组合，用于治疗或预防痛经。
• Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
  申请人：Pulaski P. Steven

  公开号：US20050014729A1

  公开（公告）日：2005-01-20

  A method for preventing or treating dermatological disorders and dermatological disorder-related complications in a subject involves a monotherapy with a Cox-2 inhibitor or a combination therapy with a Cox-2 inhibitor and a dermatological treatment agent. Also described are therapeutic compositions comprising a Cox-2 inhibitor and a dermatological treatment agent. Pharmaceutical compositions and kits for implementing the present method are also described.

  一种预防或治疗受试者的皮肤病和与皮肤病相关并发症的方法涉及使用Cox-2抑制剂进行单独治疗或与Cox-2抑制剂和皮肤治疗剂的联合治疗。还描述了包含Cox-2抑制剂和皮肤治疗剂的治疗组合物。还描述了用于实施本方法的药物组合物和工具包。
• Method for the treatment and prevention of pain and inflammation with glucosamine and a cyclooxygenase-2 selective inhibitor and compositions therefor
  申请人：Pharmacia Corporation

  公开号：US20030114418A1

  公开（公告）日：2003-06-19

  A method of treating, preventing, or inhibiting pain, inflammation or inflammation-associated disorder in a subject in need of such treatment or prevention provides for treating the subject with glucosamine and a cyclooxygenase-2 selective inhibitor or prodrug thereof, wherein the amount of glucosamine and the amount of a cyclooxygenase-2 selective inhibitor or prodrug thereof together constitute a pain or inflammation suppressing treatment or prevention effective amount of the composition. Compositions and pharmaceutical compositions that contain glucosamine and a cyclooxygenase-2 selective inhibitor are also disclosed.

  一种治疗、预防或抑制需要此类治疗或预防的受试者的疼痛、炎症或与炎症相关疾病的方法包括使用氨基葡萄糖和环氧合酶-2选择性抑制剂或其前药来治疗受试者，其中氨基葡萄糖的量和环氧合酶-2选择性抑制剂或其前药的量共同构成组合物的疼痛或炎症抑制治疗或预防的有效量。还公开了含有氨基葡萄糖和环氧合酶-2选择性抑制剂的组合物和药物组合物。
• Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate
  申请人：Pharmacia Corporation

  公开号：US20030114416A1

  公开（公告）日：2003-06-19

  A method of treating, preventing, or inhibiting pain, inflammation or inflammation-associated disorder in a subject in need of such treatment or prevention provides for treating the subject with chondroitin sulfate and a cyclooxygenase-2 selective inhibitor, or a prodrug thereof, wherein the amount of chondroitin sulfate and the amount of a cyclooxygenase-2 selective inhibitor or a pharmaceutically acceptable salt or prodrug thereof together constitute a pain or inflammation suppressing treatment or prevention effective amount. Glucosamine can optionally be present. Compositions that contain the combination of chondroitin sulfate and cyclooxygenase-2 selective inhibitor and, optionally, the glucosamine, are disclosed, as are pharmaceutical compositions.

  一种治疗、预防或抑制疼痛、炎症或与炎症相关疾病的方法，适用于需要此类治疗或预防的受试者，包括使用软骨素硫酸和环氧合酶-2选择性抑制剂或其前药来治疗受试者，其中软骨素硫酸的数量和环氧合酶-2选择性抑制剂或其药用可接受的盐或前药的数量共同构成有效的疼痛或炎症抑制治疗或预防量。可选择添加氨基葡萄糖。公开了含有软骨素硫酸和环氧合酶-2选择性抑制剂以及可选地氨基葡萄糖的组合的组合物，以及药物组合物。
• Treatment and prevention of otic disorders with Cox-2 inhibitors alone or in combination with otic agents
  申请人：Pharmacia Corporation

  公开号：US20040204471A1

  公开（公告）日：2004-10-14

  A method for preventing or treating otic disorders and otic disorder-related complications in a subject involves a monotherapy with a Cox-2 inhibitor or a combination therapy with a Cox-2 inhibitor and an otic agent. Also described are therapeutic compositions comprising a Cox-2 inhibitor and an otic agent. Pharmaceutical compositions and kits for implementing the present method are also described.

  一种用于预防或治疗主体的耳部疾病和耳部疾病相关并发症的方法涉及使用Cox-2抑制剂进行单一疗法或使用Cox-2抑制剂和耳部药剂进行联合疗法。还描述了包含Cox-2抑制剂和耳部药剂的治疗组合物。还描述了用于实施本方法的药物组合物和工具包。