3-[(E)-1-(dimethylamino)-3-(1-methylpiperidin-4-yl)-3-oxoprop-1-en-2-yl]benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(E)-1-(dimethylamino)-3-(1-methylpiperidin-4-yl)-3-oxoprop-1-en-2-yl]benzonitrile
• 化学式: C₁₈H₂₃N₃O
• 分子量: 297.4
• InChiKey: ZNSLTCAMNOCOGV-GHRIWEEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  47.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF BACTERIAL DISEASES<br/>[FR] NOUVEAUX COMPOSÉS ET NOUVELLE UTILISATION
  申请人：JANSSEN R & D IRELAND

  公开号：WO2013164337A9

  公开（公告）日：2014-09-18
• [EN] NEW COMPOUNDS AND NEW USE<br/>[FR] NOUVEAUX COMPOSÉS ET NOUVELLE UTILISATION
  申请人：JANSSEN R & D IRELAND

  公开号：WO2013164337A1

  公开（公告）日：2013-11-07

  The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein the integers are as defined in the description. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.