2-methyl-5-thiophen-3-yl-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-methyl-5-thiophen-3-yl-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]pyrrole
• 化学式: C₁₂H₁₅NS
• 分子量: 205.32
• InChiKey: QIVOZARDOXHUSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] NEW ANTIBACTERIAL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS ANTIBACTÉRIENS
  申请人：JANSSEN R & D IRELAND

  公开号：WO2014023814A1

  公开（公告）日：2014-02-13

  The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.

  本发明涉及一种可能抑制FabI酶活性的化合物（I）的新颖化合物，用于治疗细菌感染。还涉及包含这些化合物的药物组合物，以及制备这些化合物的化学过程。
• ANTIBACTERIAL COMPOUNDS
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：US20150210719A1

  公开（公告）日：2015-07-30

  The present invention is related to novel compounds of formula (I) that may inhibit the activity of the FabI enzyme, and which are useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
• US9315522B2
  申请人：——

  公开号：US9315522B2

  公开（公告）日：2016-04-19