2-diphenylphosphanyl-N-[3-[3-[(2-diphenylphosphanylacetyl)amino]propyl-methylamino]propyl]acetamide | 168099-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-diphenylphosphanyl-N-[3-[3-[(2-diphenylphosphanylacetyl)amino]propyl-methylamino]propyl]acetamide
• CAS: 168099-03-4
• 化学式: C₃₅H₄₁N₃O₂P₂
• 分子量: 597.677
• InChiKey: JANUURGQIBGHHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  42
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  61.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  氯(二甲基硫化)金(I) 、 2-diphenylphosphanyl-N-[3-[3-[(2-diphenylphosphanylacetyl)amino]propyl-methylamino]propyl]acetamide 以 二氯甲烷 为溶剂， 以95%的产率得到
  参考文献：
  名称：

  Mono-, di- and trinuclear gold(I) complexes of new phosphino-substituted amides: initial steps to chlorogold(I)diphenylphosphino-terminated dendrimers

  摘要：

  The amides MeNH-CO-square-PPh(2) (square = CH2 (2a); C6H4 (2b)) have been prepared from methylamine and alpha-diphenylphosphinoacetic acid (1a) or p-diphenylphosphino-benzoic acid (1b), respectively, using EDC (N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride) as a coupling agent. The dendritic, multifunctional species MeN(CH2CH2CH2NH-CO-square-PPh(2))(2) (5a, 5b) and N(CH2CH2NH-CO-C6H4-PPh(2))(3) (8) have been obtained following the same procedure. Treatment of the diphenylphosphino-terminated compounds with equivalent amounts of (dimethylsulfide)gold(I) chloride afforded the corresponding mono-, di- and trinuclear gold(I) complexes 3a,b, 6a,b and 9 with chain-end (diphenylphosphino)gold(I) chloride groups (-PPh(2)AuCl) in excellent yields as stable colorless solids. X-ray structure analyses have been performed for MeNH-CO-C6H4-PPh(2) (2b) (orthorhombic, space group Pna2(1)), N(CH2CH2NH-CO-C6H4-PPh(2))(3) (8) (triclinic, space group P $($) over bar$$ 1) and MeNH-CO-CH2-PPh(2)AuCl (3a) (orthorhombic, space group P2(1)2(1)2(1)). The conformation of the molecules and their packing can be rationalized on the basis of both inter- and intramolecular NH ... O hydrogen bonds, which in this case exclude intermolecular Au-1 ... An(1) contacts between the MeNH-CO-CH2-PPh(2)AuCl molecules.

  DOI：

  10.1016/0020-1693(95)90067-g

文献信息

• Mono-, di- and trinuclear gold(I) complexes of new phosphino-substituted amides: initial steps to chlorogold(I)diphenylphosphino-terminated dendrimers
  作者：Peter Lange、Annette Schier、Hubert Schmidbaur

  DOI：10.1016/0020-1693(95)90067-g

  日期：1995.7

  The amides MeNH-CO-square-PPh(2) (square = CH2 (2a); C6H4 (2b)) have been prepared from methylamine and alpha-diphenylphosphinoacetic acid (1a) or p-diphenylphosphino-benzoic acid (1b), respectively, using EDC (N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride) as a coupling agent. The dendritic, multifunctional species MeN(CH2CH2CH2NH-CO-square-PPh(2))(2) (5a, 5b) and N(CH2CH2NH-CO-C6H4-PPh(2))(3) (8) have been obtained following the same procedure. Treatment of the diphenylphosphino-terminated compounds with equivalent amounts of (dimethylsulfide)gold(I) chloride afforded the corresponding mono-, di- and trinuclear gold(I) complexes 3a,b, 6a,b and 9 with chain-end (diphenylphosphino)gold(I) chloride groups (-PPh(2)AuCl) in excellent yields as stable colorless solids. X-ray structure analyses have been performed for MeNH-CO-C6H4-PPh(2) (2b) (orthorhombic, space group Pna2(1)), N(CH2CH2NH-CO-C6H4-PPh(2))(3) (8) (triclinic, space group P $($) over bar$$ 1) and MeNH-CO-CH2-PPh(2)AuCl (3a) (orthorhombic, space group P2(1)2(1)2(1)). The conformation of the molecules and their packing can be rationalized on the basis of both inter- and intramolecular NH ... O hydrogen bonds, which in this case exclude intermolecular Au-1 ... An(1) contacts between the MeNH-CO-CH2-PPh(2)AuCl molecules.