N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(2-propan-2-ylpyrazol-3-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-yl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(2-propan-2-ylpyrazol-3-yl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-yl]benzamide
• 化学式: C₂₆H₂₆F₂N₄O₂S
• 分子量: 496.6
• InChiKey: DSMYFDBTEVMTMQ-RNHNHXFSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  93.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Heterocyclic Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds
  申请人：Pfizer Inc.

  公开号：US20150133438A1

  公开（公告）日：2015-05-14

  Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

  本文披露了具有I式结构的化合物的复合物、互变异构体和药学上可接受的盐，其定义在说明书中。还披露了相应的制药组合物、治疗方法、合成方法和中间体。
• HETEROCYCLIC SUBSTITUTED HEXAHYDROPYRANO [3,4-D][1,3]THIAZIN-2-AMINE COMPOUNDS AS INHIBITORS OF APP, BACE1 AND BACE 2.
  申请人：Pfizer Inc.

  公开号：EP2852597B1

  公开（公告）日：2016-06-08
• US8962616B2
  申请人：——

  公开号：US8962616B2

  公开（公告）日：2015-02-24
• [EN] HETEROCYCLIC SUBSTITUTED HEXAHYDROPYRANO [3,4-D] [1,3] THIAZIN- 2 -AMINE COMPOUNDS AS INHIBITORS OF APP, BACE1 AND BACE 2.<br/>[FR] COMPOSÉS D'HEXAHYDROPYRANO[3,4-D][1,3]THIAZIN-2-AMINE SUBSTITUÉS PAR DES HÉTÉROCYCLIQUES À TITRE D'INHIBITEURS D'APP, BACE1 ET BACE2
  申请人：PFIZER

  公开号：WO2013164730A1

  公开（公告）日：2013-11-07

  Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), wherein the variables R1 and R2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. The compounds of formula (I) are useful for the treatment of Alzheimer's disease or diabetes.