(3R,4R)-1-propan-2-ylpyrrolidine-3,4-diol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3R,4R)-1-propan-2-ylpyrrolidine-3,4-diol
• 化学式: C₇H₁₅NO₂
• 分子量: 145.2
• InChiKey: DHTKPHWLYRGCGI-RNFRBKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Polyene macrolide derivative
  申请人：Shionogi & Co., Ltd.

  公开号：US10246478B2

  公开（公告）日：2019-04-02

  The present invention is the following Amphotericin B derivative: wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.

  本发明是以下两性霉素 B 衍生物： 其中各符号在说明中定义。本发明化合物的第 16 位（X）是脲结构、环状结构、羟烷基或取代的单烷基氨基甲酰基。本发明化合物具有抗真菌活性。
• Chemical compound of isocitrate dehydrogenase inhibitor, and application thereof
  申请人：NANJING SANHOME PHARMACEUTICAL CO., LTD.

  公开号：US10961222B2

  公开（公告）日：2021-03-30

  Provided are a chemical compound of an isocitrate dehydrogenase inhibitor, and an application thereof, belonging to the field of medicinal chemistry; specifically provided is the chemical compound represented by formula I, or its isomer, pharmaceutically acceptable salt, crystal, solvate, or prodrug, as well as their preparation methods and pharmaceutical compositions containing said chemical compound, and an application of said chemical compound or composition. The chemical compound has very good ability to inhibit mutant IDH2 enzyme activity and to inhibit mutant IDH2 neoplastic cells, and may be used for preventing and/or treating a tumor characterized by the presence of mutant IDH2.

  本发明提供了一种属于药物化学领域的异柠檬酸脱氢酶抑制剂化合物及其应用；具体提供了式 I 所代表的化合物、 或其同分异构体、药学上可接受的盐、晶体、溶液或原药，以及它们的制备方法和含有所述化合物的药物组合物，以及所述化合物或组合物的应用。该化合物具有很好的抑制突变体 IDH2 酶活性和抑制突变体 IDH2 肿瘤细胞的能力，可用于预防和/或治疗以存在突变体 IDH2 为特征的肿瘤。
• POLYENE MACROLIDE DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：US20170190729A1

  公开（公告）日：2017-07-06

  The present invention is the following Amphotericin B derivative: wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.
• PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS
  申请人：Genentech, Inc.

  公开号：US20170283424A1

  公开（公告）日：2017-10-05

  A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 and R 3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.
• PYRROLIDINE-FUSED HETEROCYCLES
  申请人：Erasca, Inc.

  公开号：US20210292330A1

  公开（公告）日：2021-09-23

  A compound of Formula (I) is provided: where the variables are defined herein.