maleic acid (3H-quinazolin-4-ylidene)hydrazide | 960216-01-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: maleic acid (3H-quinazolin-4-ylidene)hydrazide
• 英文别名: (Z)-4-oxo-4-(2-quinazolin-4-ylhydrazinyl)but-2-enoic acid
• CAS: 960216-01-7
• 化学式: C₁₂H₁₀N₄O₃
• 分子量: 258.236
• InChiKey: HKYDVQRZLWDSMH-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  maleic acid (3H-quinazolin-4-ylidene)hydrazide 在 溶剂黄146 作用下， 以84.3%的产率得到2-(3,4-dihydro-3-oxo-2H-[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetic acid
  参考文献：
  名称：

  Novel Method for the Synthesis of [1,2,4]Triazino[4,3‐c]quinazoline System

  摘要：

  4-Hydrazinoquinazoline was found to form new 2-(3,4-dihydro-3oxo-2H[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetic acid with maleic anhydride in on-step sequence. Proposed heterocyclization includes, probably, acylation reaction followed by intramolecular uncleophilic addition.

  DOI：

  10.1080/00397910701569460
• 作为产物：
  描述：

  马来酸酐 、 4-肼基喹唑啉 以 乙醇 为溶剂， 反应 12.0h， 以93.8%的产率得到maleic acid (3H-quinazolin-4-ylidene)hydrazide
  参考文献：
  名称：

  Novel Method for the Synthesis of [1,2,4]Triazino[4,3‐c]quinazoline System

  摘要：

  4-Hydrazinoquinazoline was found to form new 2-(3,4-dihydro-3oxo-2H[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetic acid with maleic anhydride in on-step sequence. Proposed heterocyclization includes, probably, acylation reaction followed by intramolecular uncleophilic addition.

  DOI：

  10.1080/00397910701569460

文献信息

• Novel Method for the Synthesis of [1,2,4]Triazino[4,3‐<i>c</i>]quinazoline System
  作者：Sergey I. Kovalenko、Alexander V. Karpenko、Oksana V. Krivoshey、Svetlana V. Shishkina、Oleg V. Shishkin

  DOI：10.1080/00397910701569460

  日期：2007.10.1

  4-Hydrazinoquinazoline was found to form new 2-(3,4-dihydro-3oxo-2H[1,2,4]triazino[4,3-c]quinazolin-4-yl)acetic acid with maleic anhydride in on-step sequence. Proposed heterocyclization includes, probably, acylation reaction followed by intramolecular uncleophilic addition.