N-[(1R,2R)-2-(N-formylanilino)cyclohexyl]-N-phenylformamide | 1357292-05-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(1R,2R)-2-(N-formylanilino)cyclohexyl]-N-phenylformamide
• CAS: 1357292-05-7
• 化学式: C₂₀H₂₂N₂O₂
• 分子量: 322.407
• InChiKey: WSKZLIANXFEVCW-WOJBJXKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1R,2R)-1-N,2-N-二苯基环己烷-1,2-二胺 、 甲乙酐 以 二氯甲烷 为溶剂， 生成 N-[(1R,2R)-2-(N-formylanilino)cyclohexyl]-N-phenylformamide
  参考文献：
  名称：

  Novel Chiral Bisformamide-Promoted Asymmetric Allylation of Benzaldehyde with Allyltrichlorosilane

  摘要：

  Novel chiral bisformamides have been prepared from (R,R)-1,2-cyclohexanediamine and utilized as Lewis bases in the asymmetric allylation of benzaldehyde with allyltrichlorosilane. The reaction in the presence of Lewis base 1i gave an 83:17 enantiomeric ratio (R/S) of the products in 90% isolated yield.

  DOI：

  10.1080/00397911.2010.519841

文献信息

• Novel Chiral Bisformamide-Promoted Asymmetric Allylation of Benzaldehyde with Allyltrichlorosilane
  作者：Kaori Ishimaru、Kaori Ono、Yuya Tanimura、Takakazu Kojima

  DOI：10.1080/00397911.2010.519841

  日期：2011.12.15

  Novel chiral bisformamides have been prepared from (R,R)-1,2-cyclohexanediamine and utilized as Lewis bases in the asymmetric allylation of benzaldehyde with allyltrichlorosilane. The reaction in the presence of Lewis base 1i gave an 83:17 enantiomeric ratio (R/S) of the products in 90% isolated yield.