4-[4-(4-Chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]butan-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-(4-Chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]butan-2-one
• 英文别名: 4-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]butan-2-one
• 化学式: C₂₂H₂₃ClF₂O₃S
• 分子量: 440.9
• InChiKey: IVINFVROTQLPNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• THERAPEUTIC ANTI-IGF1R COMBINATIONS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20140079665A1

  公开（公告）日：2014-03-20

  The present invention provides, in part, compositions including an anti-IGF1R antibody or antigen-binding fragment thereof and any one or more of cisplatin, pemetrexed, gemcitabine and/or irinotecan; optionally including or excluding a further chemotherapeutic agent, as well as methods of treating diseases, such as cancer, using such compositions.