[3,5-Bis(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl] propanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: [3,5-Bis(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl] propanoate
• 英文别名: [3,5-bis(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl] propanoate
• 化学式: C₁₅H₁₀F₁₂O₄
• 分子量: 482.22
• InChiKey: ZHVJDZYEGDJTJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  16

文献信息

• [EN] COMPOSITE HYDROGELS FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS<br/>[FR] HYDROGELS COMPOSITES POUR L'ADMINISTRATION DE MATIÈRES BIOLOGIQUEMENT ACTIVES
  申请人：IBM

  公开号：WO2014042921A1

  公开（公告）日：2014-03-20

  A composite hydrogel comprises an amphiphilic triblock copolymer (ABA) and a loaded micelle bound by noncovalent interactions. The loaded micelle comprises a biologically active substance and an amphiphilic diblock copolymer (CD). The A blocks comprise a steroidal repeat unit (repeat unit 1) having both a backbone carbonate and a side chain bearing a steroid functional group. Each of the A blocks has a degree of polymerization of about 0.5 to about 4.0. The B block comprises a first poly(alkylene oxide) backbone. The C block comprises a second poly(alkylene oxide) backbone. The D block comprises a steroidal repeat unit (repeat unit 2) having both a backbone carbonate group and a side chain comprising a steroid functional group. The composite hydrogel is capable of controlled release of the biologically active substance.

  一种复合水凝胶包括一种亲疏性三嵌段共聚物（ABA）和一个由非共价相互作用结合的载荷胶束。所述载荷胶束包括一种生物活性物质和一种亲疏性二嵌段共聚物（CD）。所述A块包括一种类固醇重复单元（重复单元1），其具有主干碳酸酯和侧链带有类固醇官能团。每个A块的聚合度约为0.5到4.0。B块包括第一种聚（烷氧基）主干。C块包括第二种聚（烷氧基）主干。D块包括一种类固醇重复单元（重复单元2），其具有主干碳酸酯基和侧链包括类固醇官能团。该复合水凝胶能够控制释放生物活性物质。
• CONDUCTIVE POLYMER COMPOSITE AND CONDUCTIVE POLYMER COMPOSITION
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20200259094A1

  公开（公告）日：2020-08-13

  Provided are a conductive polymer composite and composition which: improve water volatilization efficiency during film formation by incorporating a novel non-doping fluorinated unit in a dopant polymer; also reduce H + generation by using the non-doping fluorinated unit in place of an acid unit generating extra acids; have good filterability and film formability; and are capable of forming a film having high transparency and good flatness when the film is formed. The conductive polymer composite is a composite containing: (A) a π-conjugated polymer; and (B) a dopant polymer which is a copolymer containing a repeating unit “a” shown by the following general formula (1) and at least one repeating unit “b” selected from repeating units shown by the following general formulae (2-1) to (2-7).
• [EN] VITAMIN FUNCTIONALIZED GEL-FORMING BLOCK COPOLYMERS FOR BIOMEDICAL APPLICATIONS<br/>[FR] COPOLYMÈRES À BLOCS FORMANT UN GEL FONCTIONNALISÉS PAR VITAMINE POUR DES APPLICATIONS BIOMÉDICALES
  申请人：IBM

  公开号：WO2014168772A1

  公开（公告）日：2014-10-16

  Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.
• [EN] WATER SOLUBLE POLYCARBONATES FOR MEDICAL APPLICATIONS<br/>[FR] POLYCARBONATES SOLUBLES DANS L'EAU POUR APPLICATIONS MÉDICALES
  申请人：IBM

  公开号：WO2016055880A1

  公开（公告）日：2016-04-14

  Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water- soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution.