(2,5-Dioxopyrrolidin-1-yl) 3-(3-methyldiaziridin-3-yl)propanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 3-(3-methyldiaziridin-3-yl)propanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3-(3-methyldiaziridin-3-yl)propanoate
• 化学式: C₉H₁₃N₃O₄
• 分子量: 227.22
• InChiKey: DFSJEQNSZTYBPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS
  申请人：ZHAO R. Yongxin

  公开号：US20170157262A1

  公开（公告）日：2017-06-08

  A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a formula (I), wherein T, L, m, n, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 12 , and R 13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

  一种具有公式（I）的细胞表面受体结合分子的强效细胞毒药物的共轭物，其中T、L、m、n、Y、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R12和R13在此定义，可用于靶向治疗癌症、自身免疫疾病和传染病。
• Conjugates of Cell Binding Molecules with Cytotoxic Agents
  申请人：Zhao R. Yongxin

  公开号：US20170296663A1

  公开（公告）日：2017-10-19

  A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , and R 13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

  一种有效的细胞毒性药物的共轭物，带有具有化学式（I）的细胞表面受体结合分子，其中T、L、m、n、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12和R13在此有定义，可用于靶向治疗癌症、自身免疫疾病和传染性疾病。
• POLYMER COATINGS
  申请人：Illumina, Inc.

  公开号：EP3792320A1

  公开（公告）日：2021-03-17

  The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.

  本公开涉及共价连接到基底表面的聚合物涂层和聚合物涂层的制备，例如聚(N-(5-叠氮乙酰胺戊基)丙烯酰胺-共丙烯酰胺)(PAZAM)，用于形成和操作基底，例如分子阵列和流动池。本公开还涉及通过使用涂有共价连接聚合物（如 PAZAM）的珠子制备基底表面的方法，以及确定附着在本文所述基底表面的多核苷酸的核苷酸序列的方法。
• Polymer coatings
  申请人：Illumina, Inc.

  公开号：US10266891B2

  公开（公告）日：2019-04-23

  The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.

  本公开涉及共价连接到基底表面的聚合物涂层和聚合物涂层的制备，例如聚(N-(5-叠氮乙酰胺戊基)丙烯酰胺-共丙烯酰胺)(PAZAM)，用于形成和操作基底，例如分子阵列和流动池。本公开还涉及通过使用涂有共价连接聚合物（如 PAZAM）的珠子制备基底表面的方法，以及确定附着在本文所述基底表面的多核苷酸的核苷酸序列的方法。
• Conjugates of cell binding molecules with cytotoxic agents
  申请人：Hangzhou DAC Biotech Co., Ltd.

  公开号：US10399941B2

  公开（公告）日：2019-09-03

  A conjugate of a potent cytotoxic agent with a cell-surface receptor binding molecule having a Formula (I), wherein T, L, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 are defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

  强效细胞毒剂与细胞表面受体结合分子的共轭物具有式（I），其中 T、L、m、n、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12 和 R13 在本文中定义，可用于癌症、自身免疫性疾病和传染性疾病的靶向治疗。