1-Propan-2-yloxyethyl 5-cyclopropyl-2-[[6-phenyl-5-(trifluoromethyl)pyridin-3-yl]amino]benzoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Propan-2-yloxyethyl 5-cyclopropyl-2-[[6-phenyl-5-(trifluoromethyl)pyridin-3-yl]amino]benzoate
• 英文别名: 1-propan-2-yloxyethyl 5-cyclopropyl-2-[[6-phenyl-5-(trifluoromethyl)pyridin-3-yl]amino]benzoate
• 化学式: C₂₇H₂₇F₃N₂O₃
• 分子量: 484.5
• InChiKey: NMUVFXDOIMCVCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• PRODRUGS OF DHODH INHIBITORS AND THEIR USES
  申请人：Palmer Alan

  公开号：US20140080768A1

  公开（公告）日：2014-03-20

  The invention generally relates to Pro-Drugs of dihydroorotate dehydrogenase (DHODH) inhibitors and methods of use thereof. In certain embodiments, the invention provides a DHODH inhibitor compound including a cleavable functional group that increases bioavailability as compared to a form of the DHODH inhibitor without the functional group, rendering the former more suitable for therapeutic use.