(Z)-4-oxo-4-[2-[4-(trifluoromethyl)benzoyl]hydrazinyl]but-2-enoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-4-oxo-4-[2-[4-(trifluoromethyl)benzoyl]hydrazinyl]but-2-enoic acid
• 化学式: C₁₂H₉F₃N₂O₄
• 分子量: 302.21
• InChiKey: BNPVHTHNCLKSID-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] METHODS OF PREPARING TECOVIRIMAT<br/>[FR] PROCÉDÉ DE PRÉPARATION DE TECOVIRIMAT
  申请人：SIGA TECHNOLOGIES INC

  公开号：WO2014028545A1

  公开（公告）日：2014-02-20

  Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

  公开了用于制备Tecovirimat以治疗或预防病毒感染及相关疾病的方法，尤其是由正痘病毒引起的病毒感染和相关疾病。
• METHOD OF PREPARING TECOVIRIMAT
  申请人：Siga Technologies, Inc.

  公开号：EP3321253A1

  公开（公告）日：2018-05-16

  Disclosed is a method for the preparation of Tecovirimat (ST-246) for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

  本发明公开了一种制备 Tecovirimat（ST-246）的方法，用于治疗或预防病毒感染和相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病。
• METHODS OF PREPARING TECOVIRIMAT
  申请人：Siga Technologies, Inc.

  公开号：EP3656763A1

  公开（公告）日：2020-05-27

  Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopox virus. The methods proceed via the synthetic intermediate 9, which has the following formula.

  本发明公开了用于治疗或预防病毒感染及相关疾病，特别是由orthopox病毒引起的病毒感染及相关疾病的Tecovirimat的制备方法。这些方法是通过合成中间体 9 进行的，中间体 9 具有下式。
• Methods of preparing Tecovirimat
  申请人：SIGA TECHNOLOGIES, INC.

  公开号：US10029985B2

  公开（公告）日：2018-07-24

  Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

  本发明公开了用于治疗或预防病毒感染和相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病的特考韦瑞马特的制备方法。
• Methods of preparing tecovirimat
  申请人：SIGA TECHNOLOGIES, INC.

  公开号：US10662155B2

  公开（公告）日：2020-05-26

  Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

  本发明公开了用于治疗或预防病毒感染和相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病的特考韦瑞马特的制备方法。