[Butanoyl(hydroxy)amino] 3-(furan-2-yl)propanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: [Butanoyl(hydroxy)amino] 3-(furan-2-yl)propanoate
• 英文别名: [butanoyl(hydroxy)amino] 3-(furan-2-yl)propanoate
• 化学式: C₁₁H₁₅NO₅
• 分子量: 241.24
• InChiKey: PGMSFSNPAQOVQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] RETRO DIELS ALDER REACTION AS A CLEAVABLE LINKER IN DNA/RNA APPLICATIONS<br/>[FR] RÉACTION DE RÉTRO-DIELS-ALDER COMME LIEUR CLIVABLE DANS DES APPLICATIONS ADN/ARN
  申请人：AGILENT TECHNOLOGIES INC

  公开号：WO2013176845A1

  公开（公告）日：2013-11-28

  The invention provides a novel approach for reversibly conjugating an oligonucleotide, which includes obtaining an oligonucleotide labeled with a diene moiety and a target entity labeled with a dienophile moiety; heating the oligonucleotide labeled with the diene moiety and the target entity labeled with the dienophile moiety in a solution at a first temperature to effect Diels Alder reaction to produce a conjugate; and heating the conjugate to a second temperature to effect retro Diels Alder reaction to regenerate the oligonucleotide labeled with the diene moiety and the target entity labeled with the dienophile moiety.