5-Tert-butyl-5-methyl-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-Tert-butyl-5-methyl-1,3-thiazolidine-2,4-dione
• 英文别名: 5-tert-butyl-5-methyl-1,3-thiazolidine-2,4-dione
• 化学式: C₈H₁₃NO₂S
• 分子量: 187.26
• InChiKey: LPKXIFKXFNBGAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Methods and compositions for terpenoid tricycloalkane synthesis
  申请人：University of Florida Research Foundation, Inc.

  公开号：US10287239B1

  公开（公告）日：2019-05-14

  In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  在一个方面，本公开涉及用于制备对萜类核心的制备有用的中间体的方法。在另一个方面，所公开的方法涉及制备包括萜类核心或支架的化合物，例如6/7/5三环脂环烷。所公开的方法利用丰富的起始材料和简单的反应序列，可用于可调和可扩展地组装常见的萜类核心。在各个方面，本公开涉及使用所公开方法制备的化合物。本摘要旨在作为搜索特定领域的扫描工具，并不意味着对本公开的限制。
• 4-SUBSTITUTED-2-THIAZOLE AMIDES AS ANTIVIRAL AGENTS
  申请人：Southern Research Institute

  公开号：US20200399264A1

  公开（公告）日：2020-12-24

  The present disclosure is concerned with benzoannulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, Eastern equine encephalitis, Western equine encephalitis, dengue, West Nile, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制病毒感染的苯并环己烯化合物，以及利用这些化合物治疗病毒感染的方法，例如印度支那病毒、委内瑞拉马脑炎、东部马脑炎、西部马脑炎、登革热、西尼罗河病毒、流感和寨卡病毒。本摘要旨在作为特定领域搜索的扫描工具，并不意味着限制本发明。
• Aryl substituted aminomethyl spectinomycin analogs as antibacterial agents
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

  公开号：US10266544B2

  公开（公告）日：2019-04-23

  The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.

  本发明涉及芳基取代的氨甲基光谱霉素类似物、其衍生物和相关化合物，可用作抗菌剂；制造这些化合物的方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗抗菌感染的方法。
• Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions
  申请人：University of Utah Research Foundation

  公开号：US10273246B2

  公开（公告）日：2019-04-30

  In one aspect, the invention relates to substituted 5H-[1,2,5]oxadiazolo [3′,4′:5,6]pyrazino[2,3-b]indole analogs, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and A methods of treating disorders, e.g., various tumors and cancers, associated with a β-catenin/T-cell factor interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及取代的5H-[1,2,5]噁二唑并[3′,4′:5,6]吡嗪并[2,3-b]吲哚类似物、其衍生物和相关化合物；制造这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和组合物治疗与β-catenin/细胞因子相互作用功能障碍相关的疾病，例如各种肿瘤和癌症的方法。本摘要旨在作为一种扫描工具，用于特定技术领域的检索，并非对本发明的限制。
• 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
  申请人：ST. JUDE CHILDREN'S RESEARCH HOSPITAL

  公开号：US10550091B2

  公开（公告）日：2020-02-04

  In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles, which are modulators the pregnane X receptor (“PXR”); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及1,4,5-取代的1,2,3-三唑和1,2,4,5-取代的咪唑，它们是孕烷X受体（"PXR"）的调节剂；制造这些化合物的合成方法；包含这些化合物的药物组合物；以及使用这些化合物和药物组合物调节哺乳动物药物不良反应的方法；使用这些化合物和药物组合物治疗细胞增殖失控疾病（如癌症）的方法；使用这些化合物和药物组合物调节哺乳动物体内孕烷 X 受体活性的方法。本摘要旨在作为一种扫描工具，用于特定技术领域的检索，并非对本发明的限制。