2,6-Difluoro-4-methylphenylacetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,6-Difluoro-4-methylphenylacetic acid
• 英文别名: 2-(2,6-difluoro-4-methylphenyl)acetic acid
• 化学式: C₉H₈F₂O₂
• 分子量: 186.15
• InChiKey: ZGAORFYBZSLXDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD OF MANUFACTURING PYRIDAZINONE COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20160060225A1

  公开（公告）日：2016-03-03

  A compound represented by formula (2) wherein X represents a hydrogen atom, a fluorine atom, a chlorine atom or a bromine atom, and Y represents a hydrogen atom, a fluorine atom, a chlorine atom or a bromine atom, is reacted with a brominating agent and an alkanol having 1 to 6 carbon atoms in the presence of a base to obtain a compound represented by formula (3) wherein R represents a C1 to C6 alkyl group, and X and Y represent the same meaning as described above, and then the compound represented by the formula (3) is reacted with hydrazine, whereby a compound represented by formula (1) wherein X and Y represent the same meaning as described above, which is useful as a production intermediate of a fungicide, can be obtained.

  将式（2）表示的化合物，其中X代表氢原子、氟原子、氯原子或溴原子，Y代表氢原子、氟原子、氯原子或溴原子，与溴化剂和具有1至6个碳原子的烷醇在碱的存在下反应，得到式（3）表示的化合物，其中R代表C1至C6烷基基团，X和Y表示如上所述的相同含义，然后将式（3）表示的化合物与肼反应，从而得到式（1）表示的化合物，其中X和Y表示如上所述的相同含义，可用作杀菌剂的生产中间体。
• US9533956B2
  申请人：——

  公开号：US9533956B2

  公开（公告）日：2017-01-03
• [EN] HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEUR UTILISATION POUR LE TRAITEMENT DE TAUOPATHIES NEURODÉGÉNÉRATIVES
  申请人：UNIV PENNSYLVANIA

  公开号：WO2014047257A2

  公开（公告）日：2014-03-27

  The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds and their use in the treatment of neurodegenerative disorders.