5-Tert-butyl-2,3-dihydro-1-benzothiophene

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-Tert-butyl-2,3-dihydro-1-benzothiophene
• 英文别名: 5-tert-butyl-2,3-dihydro-1-benzothiophene
• 化学式: C₁₂H₁₆S
• 分子量: 192.32
• InChiKey: NMENGNDCIASCNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• METHOD FOR PRODUCING INTERMEDIATE USEFUL FOR SYNTHESIS OF SGLT INHIBITOR
  申请人：Daewoong Pharmaceutical Co., Ltd.

  公开号：US20210292291A1

  公开（公告）日：2021-09-23

  A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.

  描述了一种用于合成可用作SGLT抑制剂的二苯甲烷衍生物的中间体的制备方法。合成化合物7的方法可以解决现有合成过程中需要合成格氏试剂并管理相关物质的问题。此外，该方法可以最小化相关物质的生成，因此不需要对反应产物进行再处理，从而简化了过程。因此，可以最大化二苯甲烷衍生物的产量。
• C-ARYL GLUCOSIDE DERIVATIVE, PREPARATION METHODS THEREOF, AND MEDICAL APPLICATIONS THEREOF
  申请人：JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20160222047A1

  公开（公告）日：2016-08-04

  C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I, and, tautomers, enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts of the compounds, preparation methods thereof, pharmaceutical compositions containing the compounds, and applications thereof are described. Compounds of formula (I) are useful as therapeutic agents, and particularly as sodium-dependent glucose contransporter protein (SGLT) inhibitors.

  本文描述了C-芳基葡萄糖苷衍生物，其制备方法以及医药应用。具体而言，描述了由式I表示的化合物，以及该化合物的互变异构体、对映体、非对映体、拉卡酯和药学上可接受的盐，其制备方法，含有该化合物的药物组合物以及其应用。式(I)的化合物可用作治疗剂，特别是作为钠依赖葡萄糖共转运蛋白（SGLT）抑制剂。
• NOVEL DIPHENYLMETHANE DERIVATIVES AS SGLT2 INHIBITORS
  申请人：Choi Soongyu

  公开号：US20140088079A1

  公开（公告）日：2014-03-27

  The present invention relates to a compound with a diphenylmethane moiety having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The present invention also provides a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.

  本发明涉及一种具有二苯甲烷基团的化合物，其具有对存在于肠和肾中的钠依赖性葡萄糖共转运体2（SGLT2）的抑制活性，以及包含该化合物作为活性成分的制药组合物，用于预防或治疗代谢性疾病，尤其是糖尿病。本发明还提供了一种制备该化合物的方法，以及使用该化合物预防或治疗代谢性疾病，尤其是糖尿病的方法。
• NOVEL C-ARYL ANSA SGLT2 INHIBITORS
  申请人：Kim Min Ju

  公开号：US20140213642A1

  公开（公告）日：2014-07-31

  Disclosed is a novel C-aryl ansa compound having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. Also provided are a method for preparing the compound, and a method for preventing or treating metabolic disorders, particularly diabetes, by using the compound.

  本发明涉及一种新的C-芳基ansa化合物，具有抑制肠和肾中存在的钠依赖性葡萄糖转运蛋白2（SGLT2）的活性，以及包含该化合物作为活性成分的制药组合物，该组合物对预防或治疗代谢紊乱，特别是糖尿病有用。还提供了一种制备该化合物的方法以及使用该化合物预防或治疗代谢紊乱，特别是糖尿病的方法。
• C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof
  申请人：YOUNGENE THERAPEUTICS CO., LTD

  公开号：US10011627B2

  公开（公告）日：2018-07-03

  C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I, and, tautomers, enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts of the compounds, preparation methods thereof, pharmaceutical compositions containing the compounds, and applications thereof are described. Compounds of formula (I) are useful as therapeutic agents, and particularly as sodium-dependent glucose contransporter protein (SGLT) inhibitors.

  描述了 C-芳基葡萄糖苷衍生物、其制备方法及其医学应用。具体地说，描述了式 I 所代表的化合物、化合物的同分异构体、对映体、非对映体、外消旋体和药学上可接受的盐、其制备方法、含有化合物的药物组合物及其应用。式（I）化合物可用作治疗剂，特别是钠依赖性葡萄糖转运蛋白（SGLT）抑制剂。