1-[3,4-Dihydroxy-5-(4-methylphenyl)furan-2-yl]-3-methylthiourea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[3,4-Dihydroxy-5-(4-methylphenyl)furan-2-yl]-3-methylthiourea
• 英文别名: 1-[3,4-dihydroxy-5-(4-methylphenyl)furan-2-yl]-3-methylthiourea
• 化学式: C₁₃H₁₄N₂O₃S
• 分子量: 278.33
• InChiKey: FUJVUQXYKNDWGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• [EN] FTO MODULATING COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS MODULANT FTO ET PROCÉDÉS D'UTILISATION
  申请人：UNIV MIDWESTERN

  公开号：WO2014047447A2

  公开（公告）日：2014-03-27

  The present invention relates to compounds which modulate the level or activity of polypeptides having Fe(II) and 2-oxoglutarate (2QG)-dependent oxygenase activity in a cell, tissue, or subject, exemplified by the Fat Mass and Obesity Associated protein (FTO). Aspects relate to N-(3,4-dihydroxy-5-aryl-2-furanyl)-sulfonamides, methods for their synthesis, and methods of using these compounds to modulate the activity of FTO in a cell-free sample, a cell-based assay, and in a subject. Aspects are also directed to compositions comprising compounds which modulate the activity of FTO, including pharmaceutically-acceptable compositions, and to methods of preventing, ameliorating, or treating FTO-mediated conditions or diseases in a subject, including stroke, epilepsy, depression, and degenerative central nervous system disorders such as Alzheimer's and Parkinson's disease. Other aspects elate to use of the compounds to ameliorate or treat conditions associated with metabolic disorders, such as diabetes and obesity.