1-(4-methoxyphenyl)-2-[(2-methoxyphenyl)methyl]-3H-pyrazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-methoxyphenyl)-2-[(2-methoxyphenyl)methyl]-3H-pyrazole
• 化学式: C₁₈H₂₀N₂O₂
• 分子量: 296.4
• InChiKey: CMBXTEWYZMBKGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• SMALL MOLECULE INHIBITORS OF INFLUENZA A RNA-DEPENDENT RNA POLYMERASE
  申请人：Nant Holdings IP, LLC

  公开号：US20140100228A1

  公开（公告）日：2014-04-10

  Antiviral compositions and methods are contemplated that are especially effective in the treatment and prevention of influenza A viruses. Also presented are cellular assays to identify small molecule compounds having antiviral properties, particularly as it relates to detection of influenza A RNA-dependent RNA polymerase activity in a mammalian cell independent of other influenza A components. Preferred assays allow for identification of viral replication inhibitors that do not disrupt normal cellular activity.