2,6-dimethylphenyl 2-({[4-(diethylamino)butyl]amino}methyl)pyridine-4-carboxylate | 1596348-24-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 2,6-dimethylphenyl 2-({[4-(diethylamino)butyl]amino}methyl)pyridine-4-carboxylate
• 英文别名: (2,6-Dimethylphenyl) 2-[[4-(diethylamino)butylamino]methyl]pyridine-4-carboxylate；(2,6-dimethylphenyl) 2-[[4-(diethylamino)butylamino]methyl]pyridine-4-carboxylate
• CAS: 1596348-24-1
• 化学式: C₂₃H₃₃N₃O₂
• 分子量: 383.534
• InChiKey: DVTNIFHNROCXEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] INHIBITORS OF HISTONE DEMETHYLASES<br/>[FR] INHIBITEURS D'HISTONE DÉMÉTHYLASES
  申请人：EPITHERAPEUTICS APS

  公开号：WO2014053491A1

  公开（公告）日：2014-04-10

  The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form (I).

  本申请公开了能够调节组蛋白去甲基化酶（HDMEs）活性的化合物，这些化合物对于预防和/或治疗涉及基因组失调在病因中起作用的疾病，如癌症等，是有用的。本申请还公开了包含所述化合物的药物组合物以及将这些化合物用作药物的用途。这些化合物的结构如下（I）。
• INHIBITORS OF HISTONE DEMETHYLASES
  申请人：EpiTherapeutics ApS

  公开号：US20140371195A1

  公开（公告）日：2014-12-18

  The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form

  本申请公开了能够调节组蛋白去甲基化酶(HDMEs)活性的化合物，这些化合物对于预防和/或治疗基因组失调参与病理过程的疾病，例如癌症，非常有用。本申请还公开了包含所述化合物的制药组合物，以及将这些化合物用作药物的用途。这些化合物采取以下形式。
• Inhibitors of histone demethylases
  申请人：Gilead Sciences, Inc.

  公开号：US10189787B2

  公开（公告）日：2019-01-29

  The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form

  本申请公开了能够调节组蛋白去甲基化酶（HDMEs）活性的化合物，这些化合物可用于预防和/或治疗基因组失调参与发病机制的疾病，如癌症。本申请还公开了包含上述化合物的药物组合物以及将此类化合物用作药物的方法。这些化合物的形式为