3-[4-[(2R,3S,4R,5S,6R)-6-(hydroxymethyl)-4-[[(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]-3,5-bis(phenylmethoxy)oxan-2-yl]oxyphenyl]-N-methylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[4-[(2R,3S,4R,5S,6R)-6-(hydroxymethyl)-4-[[(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]-3,5-bis(phenylmethoxy)oxan-2-yl]oxyphenyl]-N-methylbenzamide
• 化学式: C₆₂H₆₅NO₁₁
• 分子量: 1000.2
• InChiKey: MDNYPBHMATVOCJ-GJNWENEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  74
• 可旋转键数：
  23
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20140107049A1

  公开（公告）日：2014-04-17

  The present invention relates to compounds useful for the treatment or prevention of bacteria infections. The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. The invention also provides processes for making the compounds of the invention. The compounds of the present invention are represented by the following structure of Formula A: wherein the variables are as described herein.

  本发明涉及用于治疗或预防细菌感染的化合物。本发明还提供含有该化合物的药学上可接受的组合物以及使用该组合物治疗细菌感染的方法。本发明还提供制备本发明化合物的方法。本发明的化合物由以下A式结构表示：其中变量如本文所述。
• [EN] MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS<br/>[FR] DÉRIVÉS DE MANNOSE POUR TRAITER LES INFECTIONS BACTÉRIENNES
  申请人：VERTEX PHARMA

  公开号：WO2014055474A1

  公开（公告）日：2014-04-10

  The present invention relates to compounds useful for the treatment or prevention of bacteria infections. The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. The invention also provides processes for making the compounds of the invention. The compounds of the present invention are represented by the following structure of Formula (A); wherein the variables are as described herein.