1-(2-Cyanophenyl)-3-pentylthiourea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-Cyanophenyl)-3-pentylthiourea
• 英文别名: 1-(2-cyanophenyl)-3-pentylthiourea
• 化学式: C₁₃H₁₇N₃S
• 分子量: 247.36
• InChiKey: YHXLPSQWKFYVRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  79.9
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2
  申请人：Cardozo Timothy

  公开号：US20140142120A1

  公开（公告）日：2014-05-22

  The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity.
• US9216180B2
  申请人：——

  公开号：US9216180B2

  公开（公告）日：2015-12-22
• US9261497B2
  申请人：——

  公开号：US9261497B2

  公开（公告）日：2016-02-16
• [EN] PHARMACEUTICAL COMPOSITIONS AND TREATMENT OF GENETIC DISEASES ASSOCIATED WITH NONSENSE MEDIATED RNA DECAY<br/>[FR] COMPOSITIONS PHARMACEUTIQUE ET TRAITEMENT DE MALADIES GÉNÉTIQUES ASSOCIÉES À UNE DÉSINTÉGRATION D'ARN À MÉDIATION NON-SENS
  申请人：UNIV NEW YORK

  公开号：WO2014055644A2

  公开（公告）日：2014-04-10

  The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating a genetic disease caused by premature termination codons, or other conditions that render messenger ribonucleic acid (mRNA) susceptible to nonsense mediated RNA decay, in a subject. Also disclosed is a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy. The present invention also relates to a method of identifying inhibitors of nonsense mediated RNA decay and/or inducing autophagy. The present invention further relates to a method of inhibiting nonsense mediated RNA decay and/or induction of autophagy in a subject.
• [EN] METHOD OF TREATING CANCER WITH MODULATORS OF SCFSkp2<br/>[FR] MÉTHODE DE TRAITEMENT DU CANCER AVEC DES MODULATEURS DE L'ACTIVITÉ DU COMPLEXE SCF-SKP2
  申请人：UNIV NEW YORK

  公开号：WO2014062811A2

  公开（公告）日：2014-04-24

  The present invention relates to pharmaceutical compositions comprising a compound and a pharmaceutically acceptable carrier. The present invention is also directed to a method of treating cancer in a subject. Also disclosed are methods of inhibiting SCF-Skp2 activity and a method of identifying inhibitors of SCF-Skp2 activity.