formyl 5-[2-amino-3-(1H-indol-3-yl)propyl]-6-[2-(4-fluoro-3-methylphenyl)pyridin-3-yl]imidazo[1,5-a]pyridine-3-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: formyl 5-[2-amino-3-(1H-indol-3-yl)propyl]-6-[2-(4-fluoro-3-methylphenyl)pyridin-3-yl]imidazo[1,5-a]pyridine-3-carboxylate
• 化学式: C₃₂H₂₆FN₅O₃
• 分子量: 547.6
• InChiKey: YUFJXXAFVVCDGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• GDF-8 INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2903978A1

  公开（公告）日：2015-08-12
• [EN] GDF-8 INHIBITORS<br/>[FR] INHIBITEURS DE GDF-8
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2014055955A1

  公开（公告）日：2014-04-10

  Described are GCF-8 inhibitors of the formula (I), and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R5, R6, X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue.