Hydrazine, [3-(hexadecylthio)phenyl]- | 71794-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Hydrazine, [3-(hexadecylthio)phenyl]-
• 英文别名: (3-hexadecylsulfanylphenyl)hydrazine
• CAS: 71794-34-8
• 化学式: C₂₂H₄₀N₂S
• 分子量: 364.6
• InChiKey: FBSCEFJPVIUQBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.4
• 重原子数：
  25
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  63.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Estrogen receptor modulators
  申请人：CHIRON CORPORATION

  公开号：US20040077701A1

  公开（公告）日：2004-04-22

  Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

  本文描述了调节雌激素受体的吡唑化合物，以及用于治疗或预防雌激素受体介导的疾病的方法和组合物。所述化合物已被发现具有意外和惊人的调节雌激素受体活性的活性。因此，本发明的化合物在预防或治疗雌激素受体介导的疾病，如骨质疏松症、乳腺和子宫内膜癌、动脉硬化和阿尔茨海默病中具有实用性。
• ESTROGEN RECEPTOR MODULATORS
  申请人：Chiron Corporation

  公开号：US20040034081A9

  公开（公告）日：2004-02-19

  Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

  本文描述了调节雌激素受体的吡唑类化合物，以及用于治疗或预防雌激素受体介导的疾病的方法和组合物。所述化合物已被发现具有意外和惊人的调节雌激素受体活性的活性。因此，本发明的化合物在预防或治疗雌激素受体介导的疾病，如骨质疏松症、乳腺和子宫内膜癌、动脉粥样硬化和阿尔茨海默病中具有实用价值。
• Pyrazolone compounds and a process for their manufacture
  申请人：CIBA-GEIGY AG

  公开号：EP0089315A2

  公开（公告）日：1983-09-21

  Compounds of the formula where Y is a tertiary group, X is hydrogen or a leaving group, and Q is hydrogen, amidino, alkyl or aryl, there being present in Y or Q a ballasting group which comprises 10 to 30 carbon atoms, exhibit a high secondary absorption in the blue region of the visible spectrum and are useful couplers in chromogenic monochrome negative material.

  式中的化合物 其中，Y 为三级基团，X 为氢或离去基团，Q 为氢、脒基、烷基或芳基，Y 或 Q 中含有一个由 10 至 30 个碳原子组成的压载基团。
• PYRAZOLES AS ESTROGEN RECEPTOR MODULATORS
  申请人：CHIRON CORPORATION

  公开号：EP1102753A2

  公开（公告）日：2001-05-30
• US4216146A
  申请人：——

  公开号：US4216146A

  公开（公告）日：1980-08-05