N-(3,5-difluorophenyl)-5-((R)-1-((S)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)ethyl)-1H-indole-2-carboxamide | 1603833-64-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,5-difluorophenyl)-5-((R)-1-((S)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)ethyl)-1H-indole-2-carboxamide
• 英文别名: N-(3,5-difluorophenyl)-5-((R)-1-((R)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)ethyl)-1H-indole-2-carboxamide；N-(3,5-difluorophenyl)-5-[(1R)-1-[(3R)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]ethyl]-1H-indole-2-carboxamide
• CAS: 1603833-64-2
• 化学式: C₂₃H₂₂F₅N₃O
• 分子量: 451.439
• InChiKey: MXSDVGPPXMXERJ-ZFWWWQNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  48.1
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Indol-amide compounds as beta-amyloid inhbitors
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2722329A1

  公开（公告）日：2014-04-23

  The present invention provides compounds of formula (I) wherein Z, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of Alzheimer's disease.

  本发明提供了式(I)的化合物 其中Z、R1、R2和R3如本文所述，以及药用可接受的盐和酯。此外，本发明还涉及式(I)化合物的制备、包含它们的药物组合物以及它们用于治疗阿尔茨海默病作为药物的使用。
• [EN] INDOL-AMIDE COMPOUNDS AS BETA-AMYLOID INHBITORS<br/>[FR] COMPOSÉS INDOLAMIDE À UTILISER EN TANT QU'INHIBITEURS DE BÈTA-AMYLOÏDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014060386A1

  公开（公告）日：2014-04-24

  The present invention provides compounds of formula (I), wherein Z, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of Alzheimer's disease.

  本发明提供了如下式（I）的化合物，其中Z、R1、R2和R3如本文所述，以及其药用盐和酯。此外，本发明涉及制备如式（I）的化合物，包括它们的药物组合物以及它们作为治疗阿尔茨海默病的药物的用途。
• INDOL-AMIDE COMPOUNDS AS BETA-AMYLOID INHBITORS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150274661A1

  公开（公告）日：2015-10-01

  The present invention provides compounds of formula (I), wherein Z, R 1 , R 2 , and R 3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of Alzheimer's disease.

  本发明提供了式(I)的化合物，其中Z、R1、R2和R3如本文所述，以及其药学上可接受的盐和酯。此外，本发明还涉及制备式(I)的化合物、包含它们的制药组合物以及它们作为治疗阿尔茨海默病药物的用途。
• EP2909190A1
  申请人：——

  公开号：EP2909190A1

  公开（公告）日：2015-08-26