1,2,3,4,5-Pentafluoro-6-(2,3,4,5,6-pentafluorophenyl)-7-thiabicyclo[4.1.0]hepta-2,4-diene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2,3,4,5-Pentafluoro-6-(2,3,4,5,6-pentafluorophenyl)-7-thiabicyclo[4.1.0]hepta-2,4-diene
• 英文别名: 1,2,3,4,5-pentafluoro-6-(2,3,4,5,6-pentafluorophenyl)-7-thiabicyclo[4.1.0]hepta-2,4-diene
• 化学式: C₁₂F₁₀S
• 分子量: 366.18
• InChiKey: WTGOAZWINSZABF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• Modification of Peptides via SNAr Reactions of Thiols with Fluorinated Aromatics
  申请人：Pentelute Bradley L.

  公开号：US20140113871A1

  公开（公告）日：2014-04-24

  Disclosed are compounds and methods relating to a chemical transformation for the conjugation of unprotected peptide biomolecules via a S N Ar process between highly fluorinated aryl moieties and thiols (“fluoroaryl-thiol-click”).
• US9018172B2
  申请人：——

  公开号：US9018172B2

  公开（公告）日：2015-04-28
• [EN] COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES<br/>[FR] COMPOSITIONS ET MÉTHODES DE DÉTECTION ET DE TRAITEMENT DE LA THROMBOSE ET DE PLAQUES VASCULAIRES
  申请人：MICROVASCULAR THERAPEUTICS LLC

  公开号：WO2020247315A1

  公开（公告）日：2020-12-10

  The invention provides nanodroplets labeled with targeting ligands that are useful in the detection and treatment of vascular thromboses (e.g., fibrin clots) and vascular plaques, or related diseases and conditions, as well as methods of preparation and use thereof.