4-(6-Morpholin-4-ylpyridin-3-yl)-1,2,4-triazole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(6-Morpholin-4-ylpyridin-3-yl)-1,2,4-triazole-3-carboxamide
• 英文别名: 4-(6-morpholin-4-ylpyridin-3-yl)-1,2,4-triazole-3-carboxamide
• 化学式: C₁₂H₁₄N₆O₂
• 分子量: 274.28
• InChiKey: VAPXYLXSKXQXOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  99.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] TREATING POLYCYSTIC KIDNEY DISEASE WITH HSP90 INHIBITORY COMPOUNDS<br/>[FR] TRAITEMENT DE LA POLYKYSTOSE RÉNALE AVEC DES COMPOSÉS INHIBITEURS DE LA PROTÉINE HSP90
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2014063080A1

  公开（公告）日：2014-04-24

  Provided are methods of treating polycystic kidney disease in a subject in need thereof, by administering to the subject in need thereof, an effective amount of a compound according to formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables in the structural formulae are defined herein. Also provided are methods of treating polycystic kidney disease by a compound of formula (I) in combination with additional therapeutic agents.