5-fluoro-N-pyridin-2-ylpyridin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-fluoro-N-pyridin-2-ylpyridin-2-amine
• 化学式: C₁₀H₈FN₃
• 分子量: 189.19
• InChiKey: JWBASWGPXJQTIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS MACROCYCLIQUES INHIBITEURS DE PTEFB
  申请人：BAYER AG

  公开号：WO2018177889A1

  公开（公告）日：2018-10-04

  The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及一种新型改性大环化合物，其通式（I）如本文所述和定义，具有改善的耐受性，以及其制备方法，它们用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒引起的传染病和/或心血管疾病。该发明还涉及在制备通式（I）所述化合物中有用的中间化合物。
• [EN] DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFONDIIMINE GROUP<br/>[FR] DÉRIVÉS DE 5-FLUOROPYRIMIDINE DISUBSTITUÉS CONTENANT UN GROUPE SULFONE DIIMINE
  申请人：BAYER PHARMA AG

  公开号：WO2015150273A1

  公开（公告）日：2015-10-08

  The present invention relates to 5-fluoro pyrimidine derivatives containing a sulfondiimine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及一种含有通式（I）中所述和定义的磺二亚胺基团的5-氟嘧啶衍生物，以及其制备方法，其用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。该发明还涉及在制备通式（I）中所述化合物中有用的中间体化合物。
• [EN] NOVEL MACROCYCLIC COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS MACROCYCLIQUES
  申请人：BAYER PHARMA AG

  公开号：WO2015155197A1

  公开（公告）日：2015-10-15

  The present invention relates to novel macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及一种新型的大环化合物，其一般式为（I），如本文所述和定义的，以及其制备方法，用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒感染性疾病和/或心血管疾病。该发明还涉及在制备所述一般式（I）化合物中有用的中间化合物。
• [EN] NOVEL MODIFIED MACROCYCLIC COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS MACROCYCLIQUES MODIFIÉS
  申请人：BAYER PHARMA AG

  公开号：WO2017060167A1

  公开（公告）日：2017-04-13

  The present invention relates to novel modified macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及一种新型的改性大环化合物，其一般式为（I），如所述并定义，以及其制备方法，用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒引起的传染病和/或心血管疾病。该发明还涉及在制备所述一般式（I）化合物过程中有用的中间化合物。
• [EN] FLUORINATED BENZOFURANYL-PYRIMIDINE DERIVATIVES CONTAINING A SULFONE GROUP<br/>[FR] DÉRIVÉS DE BENZOFURANYLE-PYRIMIDINE FLUORÉS CONTENANT UN GROUPE SULFONE
  申请人：BAYER PHARMA AG

  公开号：WO2016059011A1

  公开（公告）日：2016-04-21

  The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I). R2 represents the group (a).

  本发明涉及含有一种磺酮基团的氟苯并呋喃基嘧啶衍生物，其通式（I）如本说明所述和定义的，以及其制备方法，其用于治疗和/或预防疾病，特别是高增殖性疾病和/或病毒感染性疾病和/或心血管疾病。本发明还涉及在制备通式（I）所述化合物中有用的中间化合物。R2代表该基团（a）。