N-phenyl-2,3-diphenyl-1,2,4-thiadiazolium-5-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-2,3-diphenyl-1,2,4-thiadiazolium-5-amine
• 英文别名: N,2,3-triphenyl-1,2,4-thiadiazol-2-ium-5-amine
• 化学式: C20H16N3S+
• 分子量: 330.4
• InChiKey: MWKGMZRDURKJEZ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE CAUSED BY YERSINIA SPP INFECTION
  申请人：Mustelin Tomas Mikael

  公开号：US20090312352A1

  公开（公告）日：2009-12-17

  The invention generally relates to compositions and methods for treatment of disease caused by Yersinia spp. infection. More specifically, the invention relates to protein tyrosine phosphatase inhibitors and derivatives and analogs thereof, pharmaceutical compositions containing the protein tyrosine phosphatase inhibitors and analogs, methods of making the protein tyrosine phosphatase inhibitors and analogs and methods of use thereof.

  本发明通常涉及用于治疗由耶尔森氏菌感染引起的疾病的组合物和方法。更具体地，本发明涉及蛋白酪氨酸磷酸酶抑制剂及其衍生物和类似物，含有蛋白酪氨酸磷酸酶抑制剂和类似物的制药组合物，制造蛋白酪氨酸磷酸酶抑制剂和类似物的方法以及使用它们的方法。
• Methods for inhibiting fascin
  申请人：Novita Pharmaceuticals, Inc.

  公开号：US10208043B2

  公开（公告）日：2019-02-19

  Provided are compositions and methods for treating a condition or disorder mediated by fascin activity in a subject in need thereof which method comprises administering to the subject a therapeutically effective amount of at least one compound of any one of Formula I-a to I-n, II, II-a, II-b or III or a pharmaceutically acceptable salt thereof.

  提供了用于治疗有需要的受试者中由 fascin 活性介导的病症或紊乱的组合物和方法，该方法包括向受试者施用治疗有效量的至少一种式 I-a 至 I-n、II、II-a、II-b 或 III 中任何一种的化合物或其药学上可接受的盐。
• METHODS FOR INHIBITING FASCIN
  申请人：Cornell University

  公开号：EP2888010A2

  公开（公告）日：2015-07-01
• Protein phosphatase inhibitors
  申请人：Yi Taolin

  公开号：US20080051464A1

  公开（公告）日：2008-02-28

  A method of inhibiting protein tyrosine phosphatase in a subject includes administering to the subject a therapeutically effective amount of at least one benzo-1,4-quinone, phenyl isothiazolone, or analog thereof to the subject.
• Non-peptidyl agents with pHSP20-like activity, and uses thereof
  申请人：von Rechenberg Moritz

  公开号：US20090136561A1

  公开（公告）日：2009-05-28

  The present invention provides compositions and methods for modulating smooth muscle cells. The present invention also provides methods of identifying small molecule candidate therapeutic agents for modulating smooth muscle.