5-ethoxycarbonyl-2,3,6-trimethyl-4-(3-nitrophenyl)-2,4-dihydro-1H-pyridine-3-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-ethoxycarbonyl-2,3,6-trimethyl-4-(3-nitrophenyl)-2,4-dihydro-1H-pyridine-3-carboxylate
• 化学式: C18H21N2O6-
• 分子量: 361.4
• InChiKey: ZWRMNVLJLKXQQU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  124
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Tegaserod for use in the treatment of nerve injuries
  申请人：Universitätsklinikum Hamburg-Eppendorf

  公开号：EP2724723A1

  公开（公告）日：2014-04-30

  This invention relates to novel pharmaceutical composition comprising tegaserod and/or a pharmaceutically acceptable salt thereof for the treatment of neurological injuries, such as traumatic and chronic lesions of the central and peripheral nervous systems and for regenerating damaged nerves and nerve function. The pharmaceutical compositions of the invention can also be used for treatment and/or prevention of acute and chronic injuries to the central and peripheral nervous systems, for promoting growth and/or regrowth of nerves and enhancing formation of synapses and synaptic plasticity, and for neuroprotection.

  本发明涉及包含替加色罗和/或其药学上可接受的盐的新型药物组合物，用于治疗神经损伤，如中枢和周围神经系统的创伤性和慢性病损，以及再生受损神经和神经功能。本发明的药物组合物还可用于治疗和/或预防中枢和周围神经系统的急性和慢性损伤，促进神经的生长和/或再生，增强突触的形成和突触的可塑性，以及用于神经保护。
• SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE NEURONAL CELLS
  申请人：The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone

  公开号：EP3039126B1

  公开（公告）日：2019-10-09