Photocrosslinkable Peptide-MHC Complexes for Antigen-Specific T Cells and Methods of Using the Same
申请人:The Board of Trustees of the Leland Stanford Junior University
公开号:US20140120557A1
公开(公告)日:2014-05-01
Methods for labeling and/or detecting a T cell according to specificity of an antigen T cell receptor (TCR) are provided. Also provided are monomeric MHC-peptide complexes and kits for crosslinking to a T cell according to specificity of an antigen T cell receptor (TCR). The methods, monomeric MHC-peptide complexes and kits find use in a variety of applications related to the detection and purification of antigen-specific T cells, such as those T cells involved in tumors, infectious diseases and autoimmune diseases.