N-hydroxy-4-[4-[4-(4-hydroxybutoxy)-2-methoxyphenyl]-2-oxopyridin-1-yl]-2-methyl-2-methylsulfonylbutanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-hydroxy-4-[4-[4-(4-hydroxybutoxy)-2-methoxyphenyl]-2-oxopyridin-1-yl]-2-methyl-2-methylsulfonylbutanamide
• 化学式: C₂₂H₃₀N₂O₈S
• 分子量: 482.5
• InChiKey: FVZOLMXJQBMJDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  33
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  151
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• N-Link Hydroxamic Acid Derivatives Useful As Antibacterial Agents
  申请人：Pfizer Inc.

  公开号：US20140128363A1

  公开（公告）日：2014-05-08

  The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.

  本发明涉及一种新的羟肟酸衍生物类，其用作LpxC抑制剂，更具体地用于治疗细菌感染。
• N-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
  申请人：Pfizer Inc.

  公开号：EP2512474B1

  公开（公告）日：2014-11-05
• NOVEL HIGH UPTAKE SULFUR SOLVENT SYSTEMS AND METHODS FOR MAKING AND USING SAME
  申请人：WEATHERFORD/LAMB, INC.

  公开号：US20140128308A1

  公开（公告）日：2014-05-08

  Compositions for chemically removing sulfur deposits from reservoir formations, production tubing, flow lines, and other production equipment due to the production of sour gas and/or oil including reaction products of diamines and aldehydes at a mole ratio between about 1:1 and about 1:6, and methods for making and using same.
• US8846933B2
  申请人：——

  公开号：US8846933B2

  公开（公告）日：2014-09-30
• US9169717B2
  申请人：——

  公开号：US9169717B2

  公开（公告）日：2015-10-27