(5E)-3-methyl-5-[(5-phenylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5E)-3-methyl-5-[(5-phenylfuran-2-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
• 化学式: C₁₅H₁₁NO₂S₂
• 分子量: 301.4
• InChiKey: IBEHYIFSXLGAMD-UKTHLTGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  90.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Novel Antiviral Agents for Enveloped Viruses
  申请人：Lee Benhur

  公开号：US20120219613A1

  公开（公告）日：2012-08-30

  Provided herein are a series of arylmethylidene rhodanine derivatives having broad-spectrum antiviral activity against enveloped viruses, including but not limited to filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, influenza A, and HIV-1. The compounds act via a novel mechanism to disrupt viral membranes and inhibit viral attachment, fusion, and/or entry into host cells. The membrane disrupting activity of the compounds is selective for viral membranes relative to other biological membranes, making the compounds non-toxic to cells and host subjects.

  本文提供了一系列具有广谱抗病毒活性的芳基甲基亚胺基罗丹宁衍生物，可对包膜病毒产生作用，包括但不限于菲洛病毒、痘病毒、汉坦病毒、布尼亚病毒、副粘病毒、黄病毒、甲型流感病毒和HIV-1。这些化合物通过一种新颖的机制来破坏病毒膜并抑制病毒附着、融合和/或进入宿主细胞。这些化合物的膜破坏活性相对于其他生物膜具有选择性，使得这些化合物对细胞和宿主主体无毒性。
• ACTIVATORS OF LATERAL ROOT FORMATION
  申请人：Audenaert Dominique

  公开号：US20100105561A1

  公开（公告）日：2010-04-29

  The present invention relates to small chemical compounds that act as activators of lateral root formation in plants. More specifically, it relates to small chemical compounds that are structurally not related to auxin but do have a similar effect on root density development in plants. Preferably, these compounds act more specifically on root development than auxin, and may have a different working mechanism.
• US8486863B2
  申请人：——

  公开号：US8486863B2

  公开（公告）日：2013-07-16
• [EN] NOVEL ANTIVIRAL AGENTS FOR ENVELOPED VIRUSES<br/>[FR] AGENTS ANTIVIRAUX INÉDITS POUR VIRUS ENVELOPPÉS
  申请人：UNIV CALIFORNIA

  公开号：WO2010044924A1

  公开（公告）日：2010-04-22

  Provided herein are a series of arylmethylidene rhodanine derivatives having broad- spectrum antiviral activity against enveloped viruses, including but not limited to fϊloviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, influenza A, and HIV- 1. The compounds act via a novel mechanism to disrupt viral membranes and inhibit viral attachment, fusion, and/or entry into host cells. The membrane disrupting activity of the compounds is selective for viral membranes relative to other biological membranes, making the compounds non-toxic to cells and host subjects.