2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-[(4-carboxyphenyl)methyl]-dimethylazanium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-[(4-carboxyphenyl)methyl]-dimethylazanium
• 化学式: C49H84NO6+
• 分子量: 783.2
• InChiKey: NYZTVPYNKWYMIW-WRBBJXAJSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  16.1
• 重原子数：
  56
• 可旋转键数：
  40
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• CORONAVIRUS VACCINE
  申请人：BioNTech RNA Pharmaceuticals GmbH

  公开号：EP3901261A1

  公开（公告）日：2021-10-27

  This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.

  该披露涉及RNA领域，用于预防或治疗冠状病毒感染。具体来说，本披露涉及用于预防冠状病毒感染和诱导有效的冠状病毒抗原特异性免疫应答（如抗体和/或T细胞应答）的方法和药剂。具体而言，在一种实施方式中，本披露涉及通过向受试者给予编码SARS-CoV-2尖刺蛋白（S蛋白）表位的肽或蛋白的RNA来诱导免疫应答，特别是在受试者中诱导对冠状病毒S蛋白的免疫应答，即编码疫苗抗原的疫苗RNA。
• [EN] MICROFLUIDIC PRODUCTION OF BIOFUNCTIONALIZED GIANT UNILAMELLAR VESICLES FOR TARGETED CARGO DELIVERY<br/>[FR] PRODUCTION MICROFLUIDIQUE DE VÉSICULES UNILAMELLAIRES GÉANTES BIOFONCTIONNALISÉES POUR UNE DISTRIBUTION DE CHARGE CIBLÉE
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2021123399A1

  公开（公告）日：2021-06-24

  The present invention relates to a method for preparation of monodisperse cell- targeting giant unilamellar vesicles based on symmetrically division of a parent polymer shell-stabilized giant unilamellar vesicle into smaller polymer shell- stabilized giant unilamellar vesicles with a diameter between 1 µm and 10 µm using a microfluidic splitting device. The inventive method allows preparation of differently charged giant unilamellar vesicles as well as bioligand- and PEG-conjugated giant unilamellar vesicles, which are useful for targeted cellular delivery at high efficiency and specificity. A further advantage of the present invention is that the giant unilamellar vesicles can deliver huge cargos such as drug releasing porous microparticles, high amounts of in vivo imaging probes, viruses, or up-and-coming DNA origami robots.

  本发明涉及一种制备单分散细胞靶向巨大单层泡囊的方法，该方法基于将母体聚合物壳稳定的巨大单层泡囊对称分裂成直径在1微米至10微米之间的较小聚合物壳稳定的巨大单层泡囊，使用微流体分裂装置。这种创新的方法允许制备带有不同电荷的巨大单层泡囊，以及生物配体和PEG共轭的巨大单层泡囊，这对于高效和特异性的靶向细胞传递非常有用。本发明的另一个优点是，巨大单层泡囊可以传递大量的货物，例如释放药物的多孔微粒、大量体内成像探针、病毒或即将推出的DNA折纸机器人。
• [EN] ALKYLATED NUCLEOSIDES, AND COMPOSITIONS AND METHODS THEREOF FOR NUCLEIC ACID DELIVERY<br/>[FR] NUCLÉOSIDES ALKYLÉS, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：MICROVASCULAR THERAPEUTICS LLC

  公开号：WO2021142059A1

  公开（公告）日：2021-07-15

  The invention provides novel compounds, compositions and formulations of liposomes, microbubbles and/or nanodroplets, and emulsions thereof, that are useful in delivery of various nucleic acids and genes (e.g., single stranded RNA, DNA, si-RNA and CRISPR constructs), as well as methods of preparation and use thereof including methods of imaging and gene delivery using ultrasound activation.

  本发明提供了新型化合物、组合物和脂质体、微气泡和/或纳米液滴以及它们的乳化物，这些化合物和组合物在传递各种核酸和基因（例如单链RNA、DNA、siRNA和CRISPR构建）方面是有用的，以及它们的制备和使用方法，包括使用超声激活的成像和基因传递方法。
• SMALL LIPID NANOPARTICLES, AND CANCER VACCINE INCLUDING SAME
  申请人：KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20220409708A1

  公开（公告）日：2022-12-29

  The present invention relates to small lipid nanoparticles, a small lipid nanoparticle (SLNP)-based nanovaccine platform including same, and a combination treatment regimen with an immune checkpoint inhibitor. Lipid nanoparticies according to the present invention can easily deliver antigens and anionic drugs into cells, and exhibit strong anti-tumor effects when loaded with tumor-associated antigens. Particularly, a cancer vaccine kit according to the present invention including lipid nanoparticles according to the present invention as a first vaccine composition and lipid nanoparticles and an immune checkpoint inhibitor as a second vaccine composition can be used to effectively suppress tumor regrowth and recurrence triggered by the occurrence of immunosuppression against a cancer nanovaccine.

  本发明涉及小型脂质纳米粒子，基于小型脂质纳米粒子（SLNP）的纳米疫苗平台，以及与免疫检查点抑制剂的联合治疗方案。根据本发明的脂质纳米粒子可以轻松地将抗原和阴离子药物输送到细胞内，并在装载肿瘤相关抗原时表现出强大的抗肿瘤效应。特别地，本发明的癌症疫苗套件包括将本发明的脂质纳米粒子作为第一疫苗组分和脂质纳米粒子以及免疫检查点抑制剂作为第二疫苗组分，可以用于有效地抑制由于癌症纳米疫苗引起的免疫抑制而引发的肿瘤再生长和复发。
• IMMUNITY ENHANCING COMPOSITION INCLUDING IMMUNE RESPONSE REGULATOR AND CATIONIC LIPOSOME, AND USE OF SAME
  申请人：Eyegene Inc.

  公开号：EP3533464A1

  公开（公告）日：2019-09-04

  The present invention relates to an immunity enhancing composition including an immune response regulator having a novel structure and, more specifically, to an immunity enhancing composition and a use of the same, wherein the immunity enhancing composition includes a lipopolysaccharide (LPS) analogue with reduced toxicity, and a cationic liposome. The present invention overcomes the physicochemical instability of a liposome, is advantageous in terms of production, transportation, and storage, and improves stability, thus being beneficial as an immune delivery system. In addition, the present invention includes an antigen, an immune response regulator, and a cationic liposome, and thus exhibits an enhanced immunity-improving effect compared to the case in which an immune response regulator is used alone.

  本发明涉及一种免疫增强组合物，其中包括一种具有新型结构的免疫反应调节剂，更具体地说，涉及一种免疫增强组合物及其用途，其中免疫增强组合物包括一种毒性降低的脂多糖（LPS）类似物和一种阳离子脂质体。本发明克服了脂质体的理化不稳定性，在生产、运输和储存方面具有优势，并提高了稳定性，因此有利于作为免疫传递系统。此外，本发明包括抗原、免疫反应调节剂和阳离子脂质体，因此与单独使用免疫反应调节剂的情况相比，本发明具有更强的免疫增强效果。