(2S)-6-amino-2-[(2-azidophenyl)methoxycarbonylamino]hexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-6-amino-2-[(2-azidophenyl)methoxycarbonylamino]hexanoic acid
• 化学式: C14H19N5O4
• 分子量: 321.33
• InChiKey: MWLJDAUNHCTXBK-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] MYOGLOBIN-BASED CATALYSTS FOR CARBENE TRANSFER REACTIONS<br/>[FR] CATALYSEURS À BASE DE MYOGLOBINE POUR RÉACTIONS DE TRANSFERT DE CARBÈNE
  申请人：UNIV ROCHESTER

  公开号：WO2016086015A1

  公开（公告）日：2016-06-02

  Methods are provided for carrying out carbene transfer transformations such as olefin cyclopropanation reactions, carbene heteroatom-H insertion reactions (heteroatom = N, S, Si), sigmatropic rearrangement reactions, and aldehyde olefination reactions with high efficiency and selectivity by using a novel class of myoglobin-based biocatalysts. These methods are useful for the synthesis of a variety of organic compounds which contain one or more new carbon-carbon or carbon-heteroatom (N, S, or Si) bond. The methods can be applied for conducting these transformations in vitro (i.e., using the biocatalyst in isolated form) and in vivo (i.e., using the biocatalyst in a whole cell system).

  提供了一种方法来进行碳烯转移反应，如烯烃环丙烷化反应，碳烯杂原子-H插入反应（杂原子= N，S，Si），σ迁移重排反应和醛烯化反应，通过使用一种新型的基于肌红蛋白的生物催化剂，可以高效和选择性地进行。这些方法对于合成含有一个或多个新碳-碳或碳-杂原子（N，S或Si）键的各种有机化合物非常有用。这些方法可以应用于体外（即使用分离形式的生物催化剂）和体内（即在整个细胞系统中使用生物催化剂）进行这些转化。
• ACTIVATABLE CRISPR/CAS9 FOR SPATIAL AND TEMPORAL CONTROL OF GENOME EDITING
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20180073002A1

  公开（公告）日：2018-03-15

  Disclosed herein is a genetically encoded light- or chemically-activated Cas9 engineered through the site-specific installation of an activatable lysine amino acid. Such activatable Cas9 proteins can be used in CRISPR/Cas9 systems to control gene expression temporally, spatially, or both. Systems, methods, kits, and compositions for manipulation of sequences and/or activities of target sequences are provided. Also provided are methods of directing CRISPR complex formation in cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas9 system.

  本文公开了一种通过位点特异性安装可活化赖氨酸氨基酸而工程化的基因编码光或化学激活的Cas9。这种可活化的Cas9蛋白质可以用于CRISPR/Cas9系统中暂时或空间地控制基因表达。本文还提供了用于操作目标序列的序列和/或活性的系统、方法、工具包和组合物。还提供了在细胞中指导CRISPR复合物形成的方法以及利用CRISPR/Cas9系统引入精确突变选择特定细胞的方法。
• IL-2 VARIANT
  申请人：Kyowa Kirin Co., Ltd.

  公开号：EP3733693A1

  公开（公告）日：2020-11-04

  The purpose of the present invention is to provide a novel IL-2 variant that has an improved selectivity for IL-2Rαβγ and selectively activates Treg. The present invention pertains to: an IL-2 variant; a method for producing the IL-2 variant; a composition containing the IL-2 variant; a therapeutic agent for an immunological disease containing the IL-2 variant; a method for elevating the selectivity of IL-2 for IL-2Rαβγ; a method for improving the affinity of IL-2 for IL-2Rα subunit; a method for lowering the affinity of IL-2 for IL-2Rβ and/or γ subunits; and a method for selectively activating a regulatory T cell.

  本发明的目的是提供一种新型IL-2变体，它对IL-2Rαβγ具有更好的选择性，并能选择性地激活Treg。本发明涉及：一种IL-2变体；一种生产该IL-2变体的方法；一种含有该IL-2变体的组合物；一种含有该IL-2变体的免疫疾病治疗剂；一种提高IL-2对IL-2Rαβγ的选择性的方法；一种提高IL-2对IL-2Rα亚基的亲和力的方法；一种降低IL-2对IL-2Rβ和/或γ亚基的亲和力的方法；以及一种选择性激活调节性T细胞的方法。
• Activatable CRISPR/CAS9 for spatial and temporal control of genome editing
  申请人：University of Pittsburgh—Of the Commonwealth System of Higher Education

  公开号：US11214779B2

  公开（公告）日：2022-01-04

  Disclosed herein is a genetically encoded light- or chemically-activated Cas9 engineered through the site-specific installation of an activatable lysine amino acid. Such activatable Cas9 proteins can be used in CRISPR/Cas9 systems to control gene expression temporally, spatially, or both. Systems, methods, kits, and compositions for manipulation of sequences and/or activities of target sequences are provided. Also provided are methods of directing CRISPR complex formation in cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas9 system.

  本文公开了一种基因编码的光激活或化学激活 Cas9，它是通过在特定位点安装可激活的赖氨酸氨基酸而设计的。这种可激活的 Cas9 蛋白可用于 CRISPR/Cas9 系统，以控制基因表达的时间、空间或两者。本文提供了用于操纵目标序列的序列和/或活性的系统、方法、试剂盒和组合物。此外，还提供了在细胞中引导 CRISPR 复合物形成的方法，以及通过利用 CRISPR/Cas9 系统引入精确突变来选择特定细胞的方法。
• ARTEMISININ DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTIMALARIAL AGENTS
  申请人：UNIVERSITY OF ROCHESTER

  公开号：EP2912169A1

  公开（公告）日：2015-09-02