Butane;2-[2-(2,6-dichloroanilino)phenyl]acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Butane;2-[2-(2,6-dichloroanilino)phenyl]acetic acid
• 英文别名: butane;2-[2-(2,6-dichloroanilino)phenyl]acetic acid
• 化学式: C18H21Cl2NO2
• 分子量: 354.3
• InChiKey: FYLXMQUPABWGLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.17
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] STABLE TRANSDERMAL PHARMACEUTICAL DRUG DELIVERY SYSTEM COMPRISING DICLOFENAC<br/>[FR] SYSTÈME TRANSDERMIQUE STABLE D'ADMINISTRATION DE MÉDICAMENTS COMPRENANT DU DICLOFÉNAC
  申请人：ZYDUS TECHNOLOGIES LTD

  公开号：WO2014068600A1

  公开（公告）日：2014-05-08

  The present invention relates to stable transdermal pharmaceutical drug delivery system of diclofenac or a pharmaceutically acceptable salt thereof. In particular, the present invention relates to a stable transdermal pharmaceutical drug delivery system of diclofenac or a pharmaceutically acceptable salt thereof which is free of any penetration enhancer. Further, the transdermal pharmaceutical drug delivery system may be free from any antioxidant. More particularly, the present invention relates to stable transdermal pharmaceutical drug delivery system of diclofenac or a pharmaceutically acceptable salt thereof, which provides an enhanced absorption of drug through skin, has a flexible backing, shows longer duration of action, and inhibits crystal formation of drug.substance during storage period.