N-((1-benzyl-1h-1,2,3-triazol-4-yl)methyl)acrylamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((1-benzyl-1h-1,2,3-triazol-4-yl)methyl)acrylamide
• 英文别名: N-[(1-benzyltriazol-4-yl)methyl]prop-2-enamide
• 化学式: C₁₃H₁₄N₄O
• 分子量: 242.28
• InChiKey: FQONYWZQDWFASV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  59.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• N-((1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)METHYL)ARYLAMIDE COMPOUNDS AS POTENTIAL ANTICANCER AGENTS AND A PROCESS FOR THE PREPARATION THEREOF
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US20150166507A1

  公开（公告）日：2015-06-18

  The present invention provides a compound of general formula 1, useful as potential anticancer agents against human cancer cell lines and process for the preparation thereof. R 1 =H, 4-F, 4-Cl, 4-Br, 4-OMe, 3-F, 2,4-diOMe, 2,5-diOMe, 3,5-diOMe, 3,4,5-triOMe, 4-ClBn R 2 =3-OPh, 4-F, 4-Cl, 4-Br, 4-OMe, 3,5-diOMe

  本发明提供了一种通用式1的化合物，可作为潜在的抗癌剂用于对抗人类癌细胞系，并提供其制备方法。R1=H, 4-F, 4-Cl, 4-Br, 4-OMe, 3-F, 2,4-diOMe, 2,5-diOMe, 3,5-diOMe, 3,4,5-triOMe, 4-ClBnR2=3-OPh, 4-F, 4-Cl, 4-Br, 4-OMe, 3,5-diOMe
• Treatment or prevention of cardiovascular events via the administration of a colchicine derivative
  申请人：Murray and Poole Enterprises, LTD.

  公开号：US11026901B2

  公开（公告）日：2021-06-08

  A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof wherein: R1, R2, R3, R4, R9, R10, R11 and R12 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, C1-4 alkyl or dialkylamino, hydroxyl, C1-4 alkoxy, C1-4 alkylthio, a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy; R7 and R8 independently represent hydrogen, C1-4 alkyl or C1-4 acyl; and R5′, R5″, R6′ and R6″ independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1-4 alkylthio a group of the formula —SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl.

  一种治疗或预防动脉粥样硬化性血管疾病患者心血管事件的方法，包括以下步骤 b) 给药治疗有效量的式（I）化合物、已知的秋水仙碱衍生物和/或其盐 其中： R1、R2、R3、R4、R9、R10、R11 和 R12 独立地代表氢、C1-4 烷基、C2-4 烯基、C3-6 环烷基、卤素、C1-4 卤代烷基、硝基、氨基、C2-4 乙酰氨基、C1-4 烷基或二烷基氨基、羟基、C1-4 烷氧基、C1-4 烷硫基、式 -SO2N(Rx)2 或 SO2Rx 的基团（其中 Rx 是 C1-4 烷基、C1-4 乙酰氧基或任选取代的苯基、任选取代的苯氧基）； R7 和 R8 独立地代表氢、C1-4 烷基或 C1-4 乙酰基；以及 R5′、R5″、R6′和 R6″ 独立地代表氢、C1-4 烷基、C2-4 烯基、C3-6 环烷基、卤素、C1-4 卤烷基、硝基、氨基、C2-4 乙酰氨基、羟基、C1-4 烷氧基或 C1-4 烷硫基，其中 Rx 是 C1-4 烷基、C1-4 乙酰氧基或任选取代的苯基。
• TREATMENT OR PREVENTION OF CARDIOVASCULAR EVENTS VIA THE ADMINISTRATION OF A COLCHICINE DERIVATIVE
  申请人：Murray & Poole Enterprises, Ltd.

  公开号：EP2914255A1

  公开（公告）日：2015-09-09
• US9309225B2
  申请人：——

  公开号：US9309225B2

  公开（公告）日：2016-04-12
• [EN] TREATMENT OR PREVENTION OF CARDIOVASCULAR EVENTS VIA THE ADMINISTRATION OF A COLCHICINE DERIVATIVE<br/>[FR] TRAITEMENT OU PRÉVENTION D'ÉVÉNEMENTS CARDIOVASCULAIRES PAR ADMINISTRATION D'UN DÉRIVÉ DE COLCHICINE
  申请人：HEART CARE WESTERN AUSTRALIA PTY LTD

  公开号：WO2014066944A1

  公开（公告）日：2014-05-08

  A method for the treatment or prevention of a cardiovascular event in a subject with atherosclerotic vascular disease comprising the step of: b) administering a therapeutically effective amount of a compound of formula (I), a known colchicine derivative and/or a salt thereof R wherein: R1, R2, R3, R4, R9, R10, R11 and R12 independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, C1-4 alkyl or dialkylamino, hydroxyl, C1-4alkoxy, C1-4 alkylthio, a group of the formula - SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl,C1-4 acyloxy, or optionally substituted phenyl, optionally substituted phenoxy; R7 and R8 independently represent hydrogen, C1-4 alkyl or C1-4 acyl; and R5', R5 ", R6' and R6" independently represent hydrogen, C1-4 alkyl, C2-4 alkenyl, C3-6 cycloalkyl, halogen, C1-4 haloalkyl, nitro, amino, C2-4 acylamino, hydroxyl, C1-4 alkoxy or C1-4 alkylthio a group of the formula -SO2N(Rx)2 or SO2Rx where Rx is C1-4 alkyl, C1-4 acyloxy, or optionally substituted phenyl.