[(2R,3S)-5-chloro-3-(4-chlorobenzoyl)oxy-2-hydroxy-5-oxopentyl] 4-chlorobenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R,3S)-5-chloro-3-(4-chlorobenzoyl)oxy-2-hydroxy-5-oxopentyl] 4-chlorobenzoate
• 化学式: C₁₉H₁₅Cl₃O₆
• 分子量: 445.7
• InChiKey: XKHUJXPOBRJELJ-CVEARBPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] FLOXURIDINE SYNTHESIS<br/>[FR] SYNTHÈSE DE FLOXURIDINE
  申请人：NUCANA PLC

  公开号：WO2019053476A1

  公开（公告）日：2019-03-21

  The present invention relates to a process for the preparation of floxuridine, said process comprising reacting a compound of Formula la with a compound of Formula lla in the presence of an acid Al to provide a compound of Formula Ilia in substantially diastereomerically pure form. Floxuridine may be useful as an anti-cancer drug. Floxuridine may also be useful in the preparation of other anti-cancer drugs, e.g. NUC-3373.

  本发明涉及一种氟尿嘧啶的制备方法，该方法包括在酸Al的存在下，使式Ia化合物与式IIa化合物发生反应，以提供基本上对映异构纯形式的式IIIa化合物。氟尿嘧啶可能作为一种抗癌药物有用。氟尿嘧啶还可能在制备其他抗癌药物，例如NUC-3373中有用。
• SYNTHESIS OF NUCLEOSIDES
  申请人：FARMABIOS S.p.A.

  公开号：US20140135490A1

  公开（公告）日：2014-05-15

  A process for the preparation of nucleosides, derivatives and analogues thereof by coupling reaction of a protected suitable nitrogeneous purine or pyrimidine base, a derivative or analogue thereof and a protected suitable sugar in the presence of SnCl 4 comprising the removal of SnCl4 by adding DMSO directly into the reaction mixture is described. Preferably said process is used for the preparation of antiviral and antitumor agents having a nucleoside or nucleoside-like structure, still more preferably for the preparation of azacytidine, decitabine, chlorfarabine, cladribine, mizoribine. A residual tin content lower than 300 ppm is obtained with said process.

  一种通过在SnCl4存在下，将受保护的适当氮碱基与其衍生物或类似物以及受保护的适当糖进行偶联反应来制备核苷、其衍生物和类似物的方法，其中通过向反应混合物中直接加入DMSO来去除SnCl4。该方法通常用于制备具有核苷或类似核苷结构的抗病毒和抗肿瘤药物，更喜欢用于制备氮杂胞苷、地西他滨、氯法比林、克拉德比林、米佐利宾。使用该方法可以获得低于300 ppm的残留锡含量。
• FLOXURIDINE SYNTHESIS
  申请人：Nucana PLC

  公开号：EP3684780A1

  公开（公告）日：2020-07-29
• CYCLIC DINUCLEOTIDES AS STING AGONISTS
  申请人：Janssen Biotech, Inc.

  公开号：EP3823976A1

  公开（公告）日：2021-05-26
• US9109000B2
  申请人：——

  公开号：US9109000B2

  公开（公告）日：2015-08-18