4-(5-{[1-(3-nitrophenyl)propyl]thio}-1,3,4-oxadiazol-2-yl)benzaldehyde | 1609537-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(5-{[1-(3-nitrophenyl)propyl]thio}-1,3,4-oxadiazol-2-yl)benzaldehyde
• 英文别名: 4-[5-[1-(3-Nitrophenyl)propylsulfanyl]-1,3,4-oxadiazol-2-yl]benzaldehyde；4-[5-[1-(3-nitrophenyl)propylsulfanyl]-1,3,4-oxadiazol-2-yl]benzaldehyde
• CAS: 1609537-18-9
• 化学式: C₁₈H₁₅N₃O₄S
• 分子量: 369.401
• InChiKey: BHMHBLTXAKFCCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  127
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• 2-THIO-1,3,4-OXADIAZOLES DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS
  申请人：Allergan, Inc.

  公开号：US20140135291A1

  公开（公告）日：2014-05-15

  The present invention relates to novel 2-thio-1,3,4-oxadiazoles derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

  本发明涉及新颖的2-硫代-1,3,4-噁二唑衍生物，其制备过程，含有它们的药物组合物以及它们作为调节鞘氨醇-1-磷酸受体的药物的用途。
• 2-THIO-1,3,4-OXADIAZOLES AZETIDINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS
  申请人：Allergan, Inc.

  公开号：US20140135365A1

  公开（公告）日：2014-05-15

  The present invention relates to 2-thio-1,3,4-oxadiazoles azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

  本发明涉及2-硫代-1,3,4-噁二唑氮杂环丙烷衍生物，其制备方法，含有它们的制药组合物以及它们作为拟调节鞘氨醇-1-磷酸受体的药物的用途。
• US8729110B1
  申请人：——

  公开号：US8729110B1

  公开（公告）日：2014-05-20
• US8846729B2
  申请人：——

  公开号：US8846729B2

  公开（公告）日：2014-09-30
• [EN] 2-THIO-1,3,4-OXADIAZOLES AZETIDINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS<br/>[FR] DÉRIVÉS 2-THIO-1,3,4-OXADIAZOLE AZÉTIDINE COMME MODULATEURS DE RÉCEPTEUR DE PHOSPHATE DE SPHINGOSINE-1
  申请人：ALLERGAN INC

  公开号：WO2014078200A1

  公开（公告）日：2014-05-22

  The present invention relates to 2-thio-1,3,4-oxadiazoles azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.