2-(1-phenyl-propylamino)-ethanol | 81133-69-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-phenyl-propylamino)-ethanol
• 英文别名: 1-Ethanolamino-1-phenyl-propan；2-(1-phenylpropylamino)ethanol
• CAS: 81133-69-9
• 化学式: C₁₁H₁₇NO
• mdl: MFCD11204355
• 分子量: 179.262
• InChiKey: OYVPCGOQMHDTDD-UHFFFAOYSA-N

物化性质

• 熔点：
  43-44 °C
• 沸点：
  159-162 °C(Press: 0.2 Torr)
• 密度：
  1.002±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 2-(1-phenyl-propylamino)-ethanol 生成 1-Oxazolidino-1-phenyl-propan
  参考文献：
  名称：

  Synthese einiger neuer N-substituierter 1-Amino-1-phenylalkane. 2. Mitteilung: 1-Oxazolidino-1-phenylalkane

  摘要：

  DOI：

  10.1002/ardp.19642970802
• 作为产物：
  描述：

  2-(苯亚甲基氨基)-乙醇 、 乙基溴化镁 生成 2-(1-phenyl-propylamino)-ethanol
  参考文献：
  名称：

  JOKUBAJTITE, S. P.;KUODIS, Z. P., TR. AN LITSSR, 1981, N 5/126, 71-80

  摘要：

  DOI：

文献信息

• Efficient preparation of secondary aminoalcohols through a Ti(IV) reductive amination procedure. Application to the synthesis and antibacterial evaluation of new 3β-N-[hydroxyalkyl]aminosteroid derivatives
  作者：Chanaz Salmi、Céline Loncle、Yves Letourneux、Jean Michel Brunel

  DOI：10.1016/j.tet.2008.02.055

  日期：2008.5

  An efficient method for the synthesis of various secondary aminoalcohols through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, different ketones gave the expected products in moderate to excellent yields up to 89% in numerous cases. A series of 3 beta-N-[hydroxyalkyl]aminosteroid derivatives were prepared according to this methodology and evaluated for their in vitro antimicrobial properties against human pathogens. All the compounds showed moderate to excellent activities against Gram-positive bacteria exhibiting similar results against Staphylococcus aureus and Streptococcus faecalis with Minimum Inhibitory Concentrations (MICs) varying from 3.12 to 25 mu g/mL. No significant antibacterial activities are encountered against Gram-negative bacteria. (c) 2008 Elsevier Ltd. All rights reserved.
• Sreekumar R.; Pillai, R. B. C.; Pillai, C. N., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, # 7, p. 692 - 693
  作者：Sreekumar R.、Pillai, R. B. C.、Pillai, C. N.

  DOI：——

  日期：——
• LIVER X RECEPTOR MODULATORS
  申请人：Vitae Pharmaceuticals, Inc.

  公开号：US20170136017A1

  公开（公告）日：2017-05-18

  Provided herein are novel compounds and pharmaceutically acceptable salts thereof that are liver X receptor modulators. Also provided are compositions comprising compounds of the invention and a carrier. Additionally, use of the compounds herein and methods for treating a disease or disorder associated with the liver X receptor are further described.
• COMPOUNDS FOR USE IN TREATING ACUTE CORONARY SYNDROME AND RELATED CONDITIONS
  申请人：Vitae Pharmaceuticals, Inc.

  公开号：US20170231992A1

  公开（公告）日：2017-08-17

  Provided herein are compounds and pharmaceutically acceptable salts thereof that are useful therapeutics for acute coronary syndrome and related disorders.
• US9814715B2
  申请人：——

  公开号：US9814715B2

  公开（公告）日：2017-11-14